Literature summary for 2.1.1.6 extracted from

Magina, S.; Vieira-Coelho, M.A.; Serrao, M.P.; Kosmus, C.; Moura, E.; Moura, D.
Ultraviolet B radiation differentially modifies catechol-O-methyltransferase activity in keratinocytes and melanoma cells (2012), Photodermatol. Photoimmunol. Photomed., 28, 137-141.

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Application

Application	Comment	Organism
medicine	both melanotic melanoma SK-mel-1 and Ha-Cat cells express COMT activity. In SK-mel-1, COMT activity is reduced nearly 50% both 24 h and 48 h after a high dose UVB. In Ha-Cat cells, COMT activity increases 24 h after a high dose UVB but decreases at 48 h. Tolcapone increases significantly the cytotoxic effect of high dose UVB irradiation only in HaCat. High concentrations of tolcapone reduce melanin levels in melanoma cells parallel to reduced cell numbers	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
tolcapone	tolcapone increases significantly the cytotoxic effect of high dose UVB irradiation in HaCat cells. High concentrations of tolcapone reduce melanin levels in melanoma cells parallel to reduced cell numbers	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HaCaT cell	-	Homo sapiens	-
SK-MEL-1 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)