Any feedback?
Literature summary for 2.1.1.6 extracted from
- Inhibition of catechol-O-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin (2014), Pharmazie, 69, 183-186.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dihydromyricetin | competitive | Homo sapiens |  |
| myricetin | competitive | Homo sapiens | |
| Myricitrin | competitive | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-dopa + S-adenosyl-L-methionine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 3-O-methyl-L-dopa | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
myricetin | 37°C, pH not specified in the publication | Homo sapiens | |
| 0.0005 | - |
Myricitrin | 37°C, pH not specified in the publication | Homo sapiens | |
| 0.0009 | - |
dihydromyricetin | 37°C, pH not specified in the publication | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
