BRENDA - Enzyme Database
show all sequences of 2.1.1.6

Methylation of catechins and procyanidins by rat and human catechol-o-methyltransferase: Metabolite profiling and molecular modeling studies

Weinert, C.; Wiese, S.; Rawel, H.; Esatbeyoglu, T.; Winterhalter, P.; Homann, T.; Kulling, S.; Drug Metab. Dispos. 40, 353-359 (2012)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Homo sapiens
5829
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
placenta
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(+)-catechin + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1
-
-
?
(+)-catechin + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1
-
-
?
(-)-epicatechin + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1
-
-
?
(-)-epicatechin + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1
-
-
?
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
733709
Homo sapiens
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
the meta/para ratio of the metabolites is approximately 4.5
-
-
?
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
the meta/para ratio of the metabolites is approximately 4.5
-
-
?
additional information
degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule
733709
Homo sapiens
?
-
-
-
-
additional information
degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule
733709
Rattus norvegicus
?
-
-
-
-
procyanidin dimer B1 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B1 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B2 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B2 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B3 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B3 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B4 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B4 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B5 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B5 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B7 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B7 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin trimer C1 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites
-
-
?
procyanidin trimer C1 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Homo sapiens
5829
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
placenta
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(+)-catechin + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1
-
-
?
(+)-catechin + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1
-
-
?
(-)-epicatechin + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1
-
-
?
(-)-epicatechin + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1
-
-
?
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
733709
Homo sapiens
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
the meta/para ratio of the metabolites is approximately 4.5
-
-
?
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
the meta/para ratio of the metabolites is approximately 4.5
-
-
?
additional information
degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule
733709
Homo sapiens
?
-
-
-
-
additional information
degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule
733709
Rattus norvegicus
?
-
-
-
-
procyanidin dimer B1 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B1 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B2 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B2 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B3 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B3 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B4 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B4 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B5 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B5 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B7 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin dimer B7 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites
-
-
?
procyanidin trimer C1 + S-adenosyl-L-methionine
-
733709
Homo sapiens
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites
-
-
?
procyanidin trimer C1 + S-adenosyl-L-methionine
-
733709
Rattus norvegicus
S-adenosyl-L-homocysteine + ?
flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites
-
-
?
Other publictions for EC 2.1.1.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733670
Pedro
-
Purification of membrane-bound ...
Homo sapiens
Chromatographia
78
1339-1348
2015
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1
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1
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1
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1
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1
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1
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1
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1
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734543
Garcia-Meseguer
Linking electrostatic effects ...
Rattus norvegicus
J. Phys. Chem. B
119
873-882
2015
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1
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1
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734783
Moskovitz
The enzymatic activities of br ...
Homo sapiens
Neuropathol. Appl. Neurobiol.
41
941-951
2015
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1
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1
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1
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735342
Qi
Salvianolic acid B as a substr ...
Rattus norvegicus
Xenobiotica
45
820-827
2015
-
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2
4
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2
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2
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2
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733795
Lorenz
The activity of catechol-O-met ...
Homo sapiens
Eur. J. Pharmacol.
740
645-651
2014
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1
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1
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3
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1
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734846
Zhu
Inhibition of catechol-O-methy ...
Homo sapiens
Pharmazie
69
183-186
2014
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3
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1
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3
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1
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1
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3
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3
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735118
Hursel
The role of catechol-O-methyl ...
Homo sapiens
PLoS ONE
9
e106220
2014
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1
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2
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735089
Schendzielorz
Catechol-O-methyltransferase ( ...
Rattus norvegicus
PLoS ONE
8
e61392
2013
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1
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3
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735306
Suriguga
The role of catechol-O-methylt ...
Homo sapiens
Toxicol. Appl. Pharmacol.
273
635-643
2013
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1
1
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718479
Ellermann
Catechol-O-methyltransferase i ...
Rattus norvegicus
Acta Crystallogr. Sect. D
68
253-260
2012
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1
1
1
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13
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1
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1
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13
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1
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1
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13
13
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732991
Robinson
Characterization of non-nitroc ...
Homo sapiens, Rattus norvegicus
ACS Chem. Neurosci.
3
129-140
2012
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7
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4
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6
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13
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13
7
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733309
Kurogi
Concerted actions of the catec ...
Homo sapiens
Biochem. Pharmacol.
84
1186-1195
2012
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-
-
-
-
-
-
-
-
1
1
-
-
-
733709
Weinert
Methylation of catechins and p ...
Homo sapiens, Rattus norvegicus
Drug Metab. Dispos.
40
353-359
2012
-
-
-
-
-
-
-
-
2
-
-
-
-
5
-
-
-
-
-
2
-
-
22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733893
Rajesh
Identification, cloning and ex ...
Penaeus monodon
Fish Shellfish Immunol.
32
693-699
2012
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
734340
Silva
Optimization of fermentation c ...
Homo sapiens
J. Biotechnol.
160
161-168
2012
-
1
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
734847
Magina
Ultraviolet B radiation differ ...
Homo sapiens
Photodermatol. Photoimmunol. Photomed.
28
137-141
2012
-
1
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
734911
Mageroy
A Solanum lycopersicum catecho ...
Solanum lycopersicum
Plant J.
69
1043-1051
2012
-
-
1
-
-
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
735069
Sparta
How metal substitution affects ...
Homo sapiens
PLoS ONE
7
e47172
2012
-
-
-
1
-
-
2
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719299
Ellermann
Molecular recognition at the a ...
Rattus norvegicus
Chemistry
17
6369-6381
2011
-
-
1
1
-
-
15
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
15
-
15
-
-
1
-
1
-
-
15
15
15
-
-
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719315
Skopec
Differential expression and ac ...
Neotoma albigula, Neotoma stephensi
Comp. Biochem. Physiol. C
154
383-390
2011
-
-
-
-
-
-
-
4
2
-
-
-
-
5
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702534
Reenilae
Simultaneous analysis of catec ...
Rattus norvegicus
Biomed. Chromatogr.
24
294-300
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702678
Huo
Proteasome inhibition in human ...
Homo sapiens
Bioorg. Med. Chem.
18
1252-1258
2010
-
-
-
-
-
-
7
-
-
-
-
-
-
3
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
7
-
-
-
-
-
-
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705247
Zeng
Expression of catechol-O-methy ...
Callithrix jacchus
J. Neural Transm.
117
45-51
2010
-
-
-
-
-
-
1
-
2
-
-
-
-
4
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705937
Meyers
Gonadectomy and hormone replac ...
Rattus norvegicus
Neuroscience
165
850-862
2010
-
-
-
-
-
-
1
-
2
-
-
-
-
3
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
718537
Li
-
Expression, purification and a ...
Penaeus chinensis
Am. J. Biochem. Biotechnol.
6
148-154
2010
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719044
Rautio
Design, synthesis and in vitro ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
2614-2616
2010
-
-
1
-
-
-
12
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
12
-
-
-
-
1
-
-
-
-
-
12
12
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719345
Zhu
O-methylation of catechol estr ...
Homo sapiens
Drug Metab. Dispos.
38
1892-1899
2010
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720182
Kiss
Discovery of a long-acting, pe ...
Rattus norvegicus
J. Med. Chem.
53
3396-3411
2010
-
-
-
-
-
-
14
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720265
Yalcin
-
Inhibition of catechol-O-methy ...
Sus scrofa domesticus
J. Mol. Catal. B
64
162-166
2010
-
-
-
-
-
-
6
2
-
-
-
-
-
1
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
3
6
1
2
-
-
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720288
Myoehaenen
Distribution of catechol-O-met ...
Mus musculus
J. Neurochem.
113
1632-1643
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684309
Halleland
Association between catechol O ...
Homo sapiens
Am. J. Med. Genet. B Neuropsychiatr. Genet.
150B
403-410
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702027
Tsuji
Crystal structures of rat cate ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
378
494-497
2009
-
-
1
1
-
-
2
-
-
1
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702121
Overbye
Phosphorylated and non-phospho ...
Rattus norvegicus
Biochem. J.
417
535-545
2009
-
-
-
-
-
-
-
-
2
-
2
-
-
2
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702948
Kaeenmaeki
Importance of membrane-bound c ...
Mus musculus
Br. J. Pharmacol.
158
1884-1894
2009
-
-
-
-
-
-
-
-
2
-
2
-
-
3
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703190
Meyer
Enantioselectivity in the meth ...
Homo sapiens
Chem. Res. Toxicol.
22
1205-1211
2009
-
-
-
-
-
-
3
6
3
-
-
-
-
2
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
3
3
-
6
3
-
-
-
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705398
Zhu
Inhibition of human catechol-O ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
113
65-74
2009
-
-
-
-
-
-
3
2
3
-
-
-
-
3
-
-
-
-
-
6
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
2
3
-
-
-
-
-
-
-
-
6
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705404
Tsuji
Crystal structures of the apo ...
Rattus norvegicus
J. Struct. Biol.
165
133-139
2009
-
-
1
1
-
-
-
-
1
-
3
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705926
Yasuda
Concerted action of the cytoso ...
Homo sapiens
Neurosci. Res.
64
273-279
2009
-
-
-
-
-
-
1
-
2
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706440
Salama
Catechol-O-methyltransferase e ...
Homo sapiens
PLoS ONE
4
e7356
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
684238
Mantione
Endogenous morphine signaling ...
Homo sapiens
Addict. Biol.
13
118-123
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684307
Pelayo-Teran
Catechol-O-methyltransferase V ...
Homo sapiens
Am. J. Med. Genet. B Neuropsychiatr. Genet.
147B
550-556
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684420
Ozkan-Ariksoysal
Design of electrochemical bios ...
Homo sapiens
Anal. Chem.
80
588-596
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685970
Lehmann
Soy isoflavones decrease the c ...
Homo sapiens
Carcinogenesis
29
363-370
2008
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687102
Cheon
Association of the catechol-O- ...
Homo sapiens
Int. Clin. Psychopharmacol.
23
291-298
2008
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1
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687176
Savitz
The relationship between child ...
Homo sapiens
Int. J. Neuropsychopharmacol.
11
149-161
2008
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1
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687949
Passarinha
A new approach on the purifica ...
Homo sapiens
J. Chromatogr. A
1177
287-296
2008
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1
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1
1
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688418
Rutherford
Crystal structures of human 10 ...
Homo sapiens, Rattus norvegicus, Sus scrofa
J. Mol. Biol.
380
120-130
2008
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1
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18
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1
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5
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3
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7
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35
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35
18
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3
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7
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688544
Papaleo
Genetic dissection of the role ...
Homo sapiens
J. Neurosci.
28
8709-8723
2008
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1
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4
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689231
Babovic
Phenotypic characterization of ...
Homo sapiens, Mus musculus
Neuroscience
155
1021-1029
2008
-
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689718
Ronkainen
Catechol-O-methyltransferase g ...
Homo sapiens
PLoS ONE
3
e1819
2008
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689989
Roussos
Prepulse inhibition of the sta ...
Homo sapiens
Psychol. Med.
38
1651-1658
2008
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702405
Doyle
Catechol-O-methyltransferase: ...
Homo sapiens
Biochim. Biophys. Acta
1780
27-33
2008
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1
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6
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6
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702413
Rutherford
The V108M mutation decreases t ...
Homo sapiens
Biochim. Biophys. Acta
1784
1098-1105
2008
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1
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1
1
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1
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703042
Ross
Genetic variation and response ...
Homo sapiens
Cancer
112
1390-1403
2008
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703319
Ho
Effects of plasticisers and re ...
Homo sapiens
Curr. Drug Metab.
9
276-279
2008
-
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5
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1
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1
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1
-
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1
-
-
703321
Ho
Estrogenic phenol and catechol ...
Homo sapiens
Curr. Drug Metab.
9
304-309
2008
-
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1
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1
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1
-
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1
-
-
703772
Salih
Expression and cyclic variatio ...
Homo sapiens
Fertil. Steril.
90
789-797
2008
-
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2
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2
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2
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3
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2
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2
-
-
704065
Salama
Catecholestrogens induce oxida ...
Homo sapiens
Int. J. Cancer
123
1246-1254
2008
-
-
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2
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2
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-
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2
2
-
-
-
706056
Sand
Alternatively spliced human ca ...
Homo sapiens
Pain
136
445-446
2008
-
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1
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2
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1
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1
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706484
Du
A catechol-O-methyltransferase ...
Homo sapiens, Mus musculus
Proc. Natl. Acad. Sci. USA
105
14609-14614
2008
-
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1
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3
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5
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5
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5
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2
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2
2
-
-
-
684299
Baud
Catechol-O-methyltransferase p ...
Homo sapiens
Am. J. Med. Genet. B Neuropsychiatr. Genet.
144B
1042-1047
2007
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1
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-
-
684302
Domschke
Meta-analysis of COMT val158me ...
Homo sapiens
Am. J. Med. Genet. B Neuropsychiatr. Genet.
144B
667-673
2007
-
1
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2
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-
-
-
-
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684378
Barnett
Gender-specific effects of the ...
Homo sapiens
Am. J. Psychiatry
164
142-149
2007
-
1
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2
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1
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-
-
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-
-
-
-
-
-
-
-
685455
Hirano
Measurement of catechol-O-meth ...
Rattus norvegicus
Biol. Pharm. Bull.
30
2178-2180
2007
-
-
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1
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2
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6
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1
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6
-
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1
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-
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-
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-
-
-
-
686075
Bai
Biochemical and molecular mode ...
Homo sapiens
Chem. Res. Toxicol.
20
1409-1425
2007
-
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1
-
-
-
-
20
2
1
2
-
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4
-
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-
1
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-
18
1
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1
14
1
-
-
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1
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-
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20
2
1
2
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1
-
-
18
1
-
-
1
14
1
-
-
-
-
-
-
-
-
-
686153
Zoccolella
Management of L-Dopa related h ...
Homo sapiens
Clin. Chem. Lab. Med.
45
1607-1613
2007
-
1
-
-
-
-
-
-
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1
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1
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-
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-
-
-
-
-
-
-
-
686194
Bonifacio
Catechol-O-methyltransferase a ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
CNS Drug Rev.
13
352-379
2007
-
-
-
-
-
-
14
22
10
-
2
-
-
6
-
1
-
-
-
8
-
-
10
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
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14
3
22
10
-
2
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1
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-
8
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686195
Apud
Treatment of cognitive deficit ...
Homo sapiens
CNS Drugs
21
535-557
2007
-
1
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-
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-
1
-
-
-
-
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2
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1
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-
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-
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-
-
-
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-
-
-
-
686865
Zahid
Inhibition of catechol-O-methy ...
Homo sapiens
Free Radic. Biol. Med.
43
1534-1540
2007
-
-
-
-
-
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1
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1
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2
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1
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1
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1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687048
Hirano
Suppression of catechol-O-meth ...
Homo sapiens, Rattus norvegicus
Hypertens. Res.
30
269-278
2007
-
-
-
-
-
-
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2
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3
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3
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2
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3
-
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-
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-
-
-
-
-
-
-
-
687140
Hirose
Effects of a catechol-O-methyl ...
Mesocricetus auratus
Int. J. Cancer
120
1627-1633
2007
-
1
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-
-
-
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1
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2
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-
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2
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2
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1
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1
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2
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687893
Lorentzon
Association between physical a ...
Homo sapiens
J. Bone Miner. Res.
22
1165-1172
2007
-
1
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-
-
-
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2
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1
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-
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-
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-
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-
-
-
-
-
-
687960
Stolk
The catechol-O-methyltransfera ...
Homo sapiens
J. Clin. Endocrinol. Metab.
92
3206-3212
2007
-
1
-
-
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-
-
-
-
-
-
-
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2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688537
Yavich
Site-specific role of catechol ...
Mus musculus
J. Neurosci.
27
10196-10209
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
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1
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-
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-
-
-
-
-
-
-
-
-
688539
Tan
Catechol-O-methyltransferase V ...
Homo sapiens
J. Neurosci.
27
13393-13401
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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1
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1
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
688540
Williams-Gray
Catechol O-methyltransferase V ...
Homo sapiens
J. Neurosci.
27
4832-4838
2007
-
1
-
-
-
-
-
-
-
-
-
-
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2
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
688679
Lu
Estrogen metabolism and format ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
105
150-158
2007
-
1
-
-
-
-
1
-
-
-
-
-
-
2
-
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1
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-
-
-
-
689173
Helkamaa
Increased catechol-O-methyltra ...
Rattus norvegicus
Neurochem. Int.
51
412-423
2007
-
1
-
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-
-
-
-
-
-
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3
-
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-
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-
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-
-
-
689314
Nackley
Catechol-O-methyltransferase i ...
Rattus norvegicus
Pain
128
199-208
2007
-
1
-
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2
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-
-
-
-
-
-
-
-
689830
Crespo-Facorro
Low-activity allele of catecho ...
Homo sapiens
Prog. Neuropsychopharmacol. Biol. Psychiatry
31
1514-1518
2007
-
-
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-
-
-
-
-
-
-
-
690007
Wentz
Treatment with an inhibitor of ...
Rattus norvegicus
Reproduction
134
831-839
2007
-
-
-
-
-
-
1
-
-
-
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3
-
-
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1
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657883
Chen
Inhibition of human liver cate ...
Homo sapiens
Biochem. Pharmacol.
69
1523-1531
2005
-
-
-
-
-
-
14
3
-
-
-
-
-
3
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3
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3
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2
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15
-
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15
14
2
3
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3
-
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3
-
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-
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-
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-
-
-
-
-
-
-
658268
Lambert
Benzotropolone inhibitors of e ...
Homo sapiens
Bioorg. Med. Chem.
13
2501-2507
2005
-
-
-
-
-
-
3
2
-
-
-
-
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2
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1
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2
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2
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657507
Chen
Functional analysis of genetic ...
Homo sapiens
Am. J. Hum. Genet.
75
807-821
2004
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
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-
4
-
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1
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1
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4
-
-
1
-
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-
-
-
-
-
-
-
-
-
-
-
-
657526
Tsunoda
An assay for determination of ...
Rattus norvegicus
Anal. Bioanal. Chem.
380
887-890
2004
-
-
-
-
-
-
-
4
2
1
-
1
-
2
-
-
-
-
-
2
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2
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-
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2
-
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4
2
1
-
1
-
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2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
658525
Nagai
Strong inhibitory effects of c ...
Homo sapiens
Drug Metab. Dispos.
32
497-504
2004
-
-
-
-
-
-
5
-
3
-
-
-
-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
7
5
-
-
3
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659347
Cotton
Oxidative inhibition of human ...
Homo sapiens
J. Biol. Chem.
279
23710-23718
2004
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
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1
-
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1
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2
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1
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1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
659631
Kim
Evidence for the existence of ...
Mycolicibacterium vanbaalenii
J. Ind. Microbiol. Biotechnol.
31
507-516
2004
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
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5
-
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1
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1
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-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660548
van Duursen
Phytochemicals inhibit catecho ...
Homo sapiens
Toxicol. Sci.
81
316-324
2004
-
-
-
-
-
-
7
-
1
-
-
1
-
3
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
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-
5
-
-
-
-
-
-
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5
7
-
-
1
-
-
1
-
-
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-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657525
Masuda
High-performance liquid chroma ...
Rattus norvegicus
Anal. Bioanal. Chem.
376
1069-1073
2003
-
-
-
-
-
-
-
14
2
1
-
-
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
14
2
1
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
657534
Wang
High-performance liquid chroma ...
Homo sapiens
Anal. Biochem.
319
13-20
2003
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
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1
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2
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1
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1
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-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658443
Yao
Catechol estrogen 4-hydroxyequ ...
Homo sapiens
Chem. Res. Toxicol.
16
668-675
2003
-
-
-
-
-
-
1
1
1
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
658517
Taskinen
Conjugation of catechols by re ...
Homo sapiens
Drug Metab. Dispos.
31
1187-1197
2003
-
-
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
45
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
45
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658520
Lu
Enzymology of methylation of t ...
Homo sapiens, Rattus norvegicus, Sus scrofa
Drug Metab. Dispos.
31
572-579
2003
-
-
-
-
-
-
7
6
3
-
-
-
-
7
-
-
-
-
-
3
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
6
3
-
-
-
-
-
-
-
-
3
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658656
Bonifacio
Kinetic inhibitory profile of ...
Rattus norvegicus
Eur. J. Pharmacol.
460
163-170
2003
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
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-
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658885
Zaccharia L.C.; Dubey
Methylation of 2-hydroxyestrad ...
Rattus norvegicus
Hypertension
42
82-87
2003
-
-
-
-
-
-
2
4
-
-
-
-
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
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-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660047
Lerner
Bisubstrate inhibitors for the ...
Homo sapiens
Org. Biomol. Chem.
1
42-49
2003
-
1
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
6
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441544
Yan
Kinetic interactions of dopami ...
Homo sapiens
J. Pharmacol. Exp. Ther.
301
315-321
2002
-
-
-
-
-
-
2
2
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
441545
Bonifacio
Expression and characterizatio ...
Rattus norvegicus, Rattus norvegicus S-COMT
Protein Expr. Purif.
23
106-112
2001
-
-
1
-
-
-
1
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441550
Dawling
Catechol-O-methyltransferase ( ...
Homo sapiens
Cancer Res.
61
6716-6722
2001
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441552
Zhao
L-Dopa upregulates the express ...
Homo sapiens
Exp. Neurol.
171
127-138
2001
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
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-
-
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-
-
-
-
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-
-
1
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441543
Bonifacio
Kinetics of rat brain and live ...
Rattus norvegicus
Arch. Biochem. Biophys.
384
361-367
2000
-
-
-
-
-
-
-
8
-
-
-
-
-
3
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441547
Zhu
O-Methylation of tea polypheno ...
Homo sapiens
Drug Metab. Dispos.
28
1024-1030
2000
-
-
-
-
-
-
1
2
2
-
-
-
-
3
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
2
-
-
-
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441551
Dhar
Purification and characterizat ...
Streptomyces griseus, Streptomyces griseus S-COMT
Appl. Environ. Microbiol.
66
4877-4882
2000
-
-
-
-
-
-
4
3
-
1
1
-
-
3
-
-
1
-
-
-
-
-
6
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
4
1
3
-
1
1
-
-
-
-
1
-
-
-
-
6
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
441540
Percy
Catechol-O-methyltransferase a ...
Cricetulus griseus
Br. J. Pharmacol.
128
774-780
1999
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441542
Weinshilboum
Methylation pharmacogenetics: ...
Homo sapiens, Rattus norvegicus
Annu. Rev. Pharmacol. Toxicol.
39
19-52
1999
-
-
2
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441553
Borges
Rat liver catechol-O-methyltra ...
Rattus norvegicus
J. Enzyme Inhib.
13
473-483
1998
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441539
Ulmanen
Expression and intracellular l ...
Homo sapiens, Rattus norvegicus
Eur. J. Biochem.
243
452-459
1997
-
-
-
-
-
-
-
-
10
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441548
Eshleman
Metabolism of catecholamines b ...
Homo sapiens
J. Neurochem.
69
1459-1466
1997
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441555
Zheng
-
A theoretical examiniation of ...
Rattus norvegicus
J. Am. Chem. Soc.
119
8137-8145
1997
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441549
Tilgmann
Purification methods of mammal ...
Homo sapiens, Rattus norvegicus
J. Chromatogr. B
684
147-161
1996
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441546
Lotta
Kinetics of human soluble and ...
Homo sapiens
Biochemistry
34
4202-4210
1995
-
-
-
-
-
-
1
1
-
-
-
-
-
3
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441538
Vidgren
Crystal structure of catechol ...
Homo sapiens
Nature
368
354-358
1994
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441541
Karhunen
Distribution of catechol-O-met ...
Rattus norvegicus
J. Histochem. Cytochem.
42
1079-1090
1994
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441554
Zhu
Catechol-O-methyltransferase-c ...
Cricetinae, Sus scrofa
J. Biol. Chem.
269
292-299
1994
-
-
-
-
-
-
-
2
-
-
-
-
-
5
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441511
Lundström
Expression of enzymatically ac ...
Homo sapiens, Rattus norvegicus
Biochim. Biophys. Acta
1129
149-154
1992
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
2
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441510
Bhaird
Catechol-O-methyltransferase f ...
Homo sapiens
Biochem. Soc. Trans.
19
20S
1991
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
1
1
-
2
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441512
Bertocci
Immunoaffinity purification an ...
Homo sapiens, Sus scrofa
Biochim. Biophys. Acta
1080
103-109
1991
-
-
-
-
-
-
-
-
6
-
1
-
-
5
-
-
1
-
-
4
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
1
-
4
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441519
Tilgmann
Purification and partial seque ...
Homo sapiens
Biochem. Biophys. Res. Commun.
174
995-1002
1991
1
-
-
-
-
-
-
-
1
-
1
-
-
3
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441527
Tilgmann
Purification and partial chara ...
Homo sapiens, Rattus norvegicus
FEBS Lett.
264
95-99
1990
-
-
-
-
-
-
-
-
2
-
1
-
-
3
-
-
1
-
-
3
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
1
-
3
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441529
Nic A'Bhaird
Behavior and properties of cat ...
Homo sapiens
J. Neural Transm.
32
359-368
1990
1
-
-
-
-
-
1
-
-
1
1
-
-
2
-
-
1
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
1
1
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441530
Piedrafita
Inhibition of catechol-O-methy ...
Sus scrofa
J. Enzyme Inhib.
4
43-50
1990
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441520
Sanft
Competitive inhibition of cate ...
Rattus norvegicus
Z. Naturforsch. C
44
173-176
1989
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441531
Schultz
Inhibition of rat liver and du ...
Rattus norvegicus
Biochem. Pharmacol.
38
3953-3956
1989
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441532
Timmers
-
Kinetic studies of catechol-O- ...
Clarias gariepinus
Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol.
91
399-402
1988
-
-
-
-
-
-
1
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441533
Rhee
-
Rat liver catechol-O-methyltra ...
Rattus norvegicus
Hanguk Saenghwahakhoe Chi
21
60-67
1988
-
-
-
-
-
-
3
2
-
1
1
-
-
1
-
-
1
-
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
2
-
1
1
-
-
-
-
1
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
441525
Veser
Kinetics and inhibition studie ...
Candida tropicalis
J. Bacteriol.
169
3696-3700
1987
-
-
-
-
-
-
15
4
-
3
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
15
2
4
-
3
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441518
Raxworthy
The effect of bulk hydrogen io ...
Sus scrofa
Biochim. Biophys. Acta
870
417-425
1986
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441534
Jeffrey
Purification and kinetic mecha ...
Homo sapiens
J. Neurochem.
44
881-885
1985
-
-
-
-
-
-
1
-
1
-
1
-
-
2
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441535
Jeffrey
Characterization of membrane-b ...
Homo sapiens
J. Neurochem.
42
826-832
1984
-
-
-
-
-
-
5
1
1
1
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
1
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
441536
Tunnicliff
Kinetics of rat brain soluble ...
Rattus norvegicus
Int. J. Biochem.
15
733-738
1983
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441524
Rivett
Kinetic studies on the O-methy ...
Homo sapiens
Biochemistry
21
1740-1742
1982
-
-
-
-
-
-
2
3
1
-
-
-
-
2
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
3
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441537
Borchardt
Catechol O-methyltransferase. ...
Rattus norvegicus
J. Med. Chem.
25
258-263
1982
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
2
-
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441509
Borchardt
Catechol O-methyltransferase ...
Rattus norvegicus
Methods Enzymol.
77
267-272
1981
-
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6
-
-
1
1
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-
1
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-
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4
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6
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1
1
4
1
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441508
Huh
Multiple molecular forms of ca ...
Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
J. Biol. Chem.
254
299-308
1979
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2
-
2
6
-
5
-
-
1
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12
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6
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12
2
1
6
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441526
Veser
Purification and properties of ...
Candida tropicalis
Z. Naturforsch. C
34
709-714
1979
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4
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6
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1
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441513
Gulliver
The purification and propertie ...
Sus scrofa
Eur. J. Biochem.
88
439-444
1978
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1
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441514
Borchardt
Purification and characterizat ...
Rattus norvegicus
Biochim. Biophys. Acta
522
49-62
1978
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3
4
2
-
1
-
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3
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6
1
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6
1
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441515
Tong
Solubilization and partial pur ...
Rattus norvegicus
Can. J. Biochem.
55
1108-1113
1977
-
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-
6
1
1
1
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2
-
2
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1
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2
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1
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6
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1
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2
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1
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441516
Buu
Competitive inhibition of cate ...
Rattus norvegicus
Can. J. Biochem.
55
771-773
1977
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6
1
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-
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3
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6
3
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441517
Borchardt
Purification of catechol-O-met ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
63
69-77
1975
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441528
Lin
Specific tlc, gc, and gc-ms me ...
Homo sapiens, Platyrrhini
Anal. Biochem.
57
46-58
1974
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2
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441522
Coward
Kinetic studies on catechol O- ...
Rattus norvegicus
Biochemistry
12
2291-2297
1973
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1
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441521
Schwabe
Catechol-O-methyltransferase, ...
Rattus norvegicus
Hoppe-Seyler's Z. Physiol. Chem.
353
476-482
1972
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-
2
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-
-
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441523
Ball
Kinetic properties of a solubl ...
Homo sapiens
Eur. J. Biochem.
26
560-569
1972
1
-
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-
-
-
5
1
1
2
-
-
-
2
-
-
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2
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5
1
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441507
Axelrod
Enzymatic O-methylation of epi ...
Bos taurus, Cavia porcellus, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
233
702-705
1958
-
-
-
-
-
-
12
1
-
9
-
-
-
7
-
-
-
-
-
17
-
1
25
-
-
-
1
-
1
-
-
-
-
-
-
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12
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9
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17
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1
25
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1
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1
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