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Literature summary for 2.1.1.6 extracted from

  • Yasuda, S.; Yasuda, T.; Hui, Y.; Liu, M.Y.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
    Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells (2009), Neurosci. Res., 64, 273-279.
    View publication on PubMed
Search for more literature for 2.1.1.6

Inhibitors

Inhibitors Comment Organism Structure
tropolone complete inhibition at 0.25 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol the majority of COMT dopamine-methylating activity is found to be present in the cytosol Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SK-N-MC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dopamine + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + 3-O-methyldopamine
-
 ?

Synonyms

Synonyms Comment Organism
COMT
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism concerted action of cytosolic sulfotransferase SULT1A3 and COMT in dopamine metabolism Homo sapiens