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Literature summary for 2.1.1.6 extracted from

  • Lu, F.; Zahid, M.; Saeed, M.; Cavalieri, E.L.; Rogan, E.G.
    Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition (2007), J. Steroid Biochem. Mol. Biol., 105, 150-158.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine COMT activity and increased formation of depurinating adducts can be critical factors leading to initiation of breast cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ro41-0960
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-10F cell estradiol-treated Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyestradiol + S-adenosyl-L-methionine
-
Homo sapiens S-adenosyl-L-homocysteine + ?
-
?

Synonyms

Synonyms Comment Organism
COMT
-
Homo sapiens