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Literature summary for 2.1.1.6 extracted from
- Suppression of catechol-O-methyltransferase activity through blunting of alpha2-adrenoceptor can explain hypertension in Dahl salt-sensitive rats (2007), Hypertens. Res., 30, 269-278.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound to | Homo sapiens | 16020 | - |
| membrane | bound to | Rattus norvegicus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | norepinephrine stimulates alpha2-adrenoceptor of the cells to increase the MB-COMT activity, but not the level of MB-COMT mRNA transcription | Homo sapiens | - |
| kidney | high-salt loading significantly suppresses the activities of membrane-bound COMT and increases the urinary norepinephrine level in Dahl salt-sensitive rats | Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MB-COMT | - |
Homo sapiens |
| MB-COMT | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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