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Literature summary for 2.1.1.6 extracted from

  • Zahid, M.; Saeed, M.; Lu, F.; Gaikwad, N.; Rogan, E.; Cavalieri, E.
    Inhibition of catechol-O-methyltransferase increases estrogen-DNA adduct formation (2007), Free Radic. Biol. Med., 43, 1534-1540.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.6

Inhibitors

Inhibitors Comment Organism Structure
Ro41-0960 blocks the methoxylation of catechol estrogens, with concomitant 3fold to 4fold increases in the levels of the depurinating adducts. Low activity of COMT leads to higher levels of depurinating estrogen-DNA adducts that can induce mutations and initiate cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyestradiol + S-adenosyl-L-methionine Homo sapiens MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts (17beta)-estra-1(10),2,4-triene-3,4,17-triol + S-adenosyl-L-homocysteine + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-10F cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyestradiol + S-adenosyl-L-methionine MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts Homo sapiens (17beta)-estra-1(10),2,4-triene-3,4,17-triol + S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

Synonyms Comment Organism
COMT
-
 Homo sapiens