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Literature summary for 2.1.1.6 extracted from
- Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells (2008), Carcinogenesis, 29, 363-370.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| daidzein | soy isoflavones at hormonally active concentrations cause a significant reduction of both COMT mRNA levels and COMT activity as well as of the methylation of 4-hydroxyestradiol | Homo sapiens |  |
| genistein | soy isoflavones at hormonally active concentrations cause a significant reduction of both COMT mRNA levels and COMT activity as well as of the methylation of 4-hydroxyestradiol | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyestradiol + S-adenosyl-L-methionine | Homo sapiens | in the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase. in the isoflavone-induced. The estrogen receptor is involved in the down-regulation of COMT expression | S-adenosyl-L-homocysteine + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-7 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyestradiol + S-adenosyl-L-methionine | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| 4-hydroxyestradiol + S-adenosyl-L-methionine | in the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase. in the isoflavone-induced. The estrogen receptor is involved in the down-regulation of COMT expression | Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COMT | - |
Homo sapiens |
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