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Literature summary for 2.1.1.6 extracted from
- Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage (2004), Toxicol. Sci., 81, 316-324.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| catechin | IC50: 0.00164 mM | Homo sapiens |  |
| chrysin | slight inhibition at 0.3 mM | Homo sapiens | |
| epicatechin | IC50: 0.00196 mM | Homo sapiens | |
| flavone | IC50: 0.00549 mM | Homo sapiens | |
| genistein | slight inhibition at 0.3 mM | Homo sapiens | |
| quercetin | IC50: 0.00048 mM | Homo sapiens | |
| Ro 41-0960 | IC50: 5-42 nM | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme plays an important role in the inactivation potentially genotoxic catechol estrogens | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mammary gland | healthy | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme plays an important role in the inactivation potentially genotoxic catechol estrogens | Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine + 2-hydroxyestradiol | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + 4-hydroxyestradiol | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COMT | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000005 | 0.000042 | IC50: 5-42 nM | Homo sapiens | Ro 41-0960 | |
| 0.00048 | - |
IC50: 0.00048 mM | Homo sapiens | quercetin | |
| 0.00164 | - |
IC50: 0.00164 mM | Homo sapiens | catechin | |
| 0.00196 | - |
IC50: 0.00196 mM | Homo sapiens | epicatechin | |
| 0.00549 | - |
IC50: 0.00549 mM | Homo sapiens | flavone | |
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