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Literature summary for 2.1.1.6 extracted from

  • Lambert, J.D.; Chen, D.; Wang, C.Y.; Ai, N.; Sang, S.; Ho, C.T.; Welsh, W.J.; Yang, C.S.
    Benzotropolone inhibitors of estradiol methylation: kinetics and in silico modeling studies (2005), Bioorg. Med. Chem., 13, 2501-2507.
    View publication on PubMed
Search for more literature for 2.1.1.6

Inhibitors

Inhibitors Comment Organism Structure
purpurogallin decreased Vmax and increased Km-value Homo sapiens
purpurogallin carboxylic acid
-
 Homo sapiens
theaflavin-3,3'-digallate decreased Vmax and increased Km-value Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0161
-
 4-hydroxyestradiol
-
 Homo sapiens
0.0175
-
 2-hydroxyestradiol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 2-hydroxyestradiol
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + 4-hydroxyestradiol
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?