Literature summary for 2.1.1.56 extracted from

Trotman, J.B.; Giltmier, A.J.; Mukherjee, C.; Schoenberg, D.R.
RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs (2017), Nucleic Acids Res., 45, 10726-10739 .

Search for more literature for 2.1.1.56

Activating Compound

Activating Compound	Comment	Organism	Structure
RNMT-activating miniprotein	the presence of RNMT-activating miniprotein is required for cytoplasmic cap methyltransferase activity	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells and Escherichia coli	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme is responsible for guanine-N7 methylation of recapped mRNAs	?	-	-
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA]	Homo sapiens	-	S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
U2-OS cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is responsible for guanine-N7 methylation of recapped mRNAs	Homo sapiens	?	-	-
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA]	-	Homo sapiens	S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA]	-	?
S-adenosyl-L-methionine + Gppp-RNA	-	Homo sapiens	S-adenosyl-L-homocysteine + m7Gppp-RNA	-	?

Subunits

Subunits	Comment	Organism
?	x * 75000, GST-tagged enzyme, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
cap methyltransferase	-	Homo sapiens
RNA guanine-7 methyltransferase	-	Homo sapiens
RNMT	-	Homo sapiens

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Release 2023.1 (January 2023)