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Literature summary for 2.1.1.56 extracted from

  • Yokoska, J.i.; Tsukamoto, T.; Miura, K.i.; Shiokawa, K.; Mizumoto, K.
    Cloning and characterization of mRNA capping enzyme and mRNA (guanine-7-)-methyltransferase cDNAs from Xenopus laevis (2000), Biochem. Biophys. Res. Commun., 268, 617-624.
    View publication on PubMed
Search for more literature for 2.1.1.56

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, His-tagged Xenopus laevis
expression in Escherichia coli, His-tagged, amino acid sequence analysis Xenopus laevis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 Western blot Xenopus laevis
58660 60000 DNA sequence determination, western blot Xenopus laevis
68820 70000 DNA sequence determination, western blot Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Xenopus laevis methylation of the cap structure is also implicated in polyadenylation-mediated translational activation during Xenopus oocyte maturation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q9I8S2 fragment of 402 amino acids
-
Xenopus laevis Q9IA92 mRNA (guanine-7-)methyltransferase component of the capping enzyme
-
Xenopus laevis Q9IA93 mRNAcapping enzyme
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] RNA triphosphatase, RNA guanylyltransferase, and RNA (guanine-N7-)methyltransferase form the mRNA capping enzyme complex consiting of a small and a large subunit Xenopus laevis
a

Source Tissue

Source Tissue Comment Organism Textmining
zygote
-
 Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information methylation of the cap structure is also implicated in polyadenylation-mediated translational activation during Xenopus oocyte maturation Xenopus laevis ?
-
 ?
S-adenosyl-L-methionine + G(5')pppR-RNA
-
 Xenopus laevis S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
 ?