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Literature summary for 2.1.1.53 extracted from
- Putrescine N-methyltransferase--the start for alkaloids (2009), Phytochemistry, 70, 1708-1718.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Capsicum annuum |
| expressed in Escherichia coli | Ipomoea batatas |
| expressed in Escherichia coli | Atropa belladonna |
| expressed in Escherichia coli | Hyoscyamus niger |
| expressed in Escherichia coli | Nicotiana sylvestris |
| expressed in Escherichia coli | Physalis divaricata |
| expressed in Escherichia coli | Anisodus tanguticus |
| expressed in Escherichia coli | Calystegia sepium |
| expressed in Escherichia coli | Datura inoxia |
| expressed in Escherichia coli | Datura stramonium |
| expressed in Escherichia coli | Solanum lycopersicum |
| expressed in Escherichia coli | Solanum tuberosum |
| expressed in Escherichia coli | Datura metel |
| expressed in Escherichia coli | Nicotiana attenuata |
| expressed in Escherichia coli | Nicotiana benthamiana |
| expressed in Escherichia coli | Nicotiana tabacum |
| expressed in Escherichia coli | Scopolia parviflora |
| expressed in Escherichia coli | Solanum dulcamara |
| expressed in Escherichia coli | Anisodus acutangulus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,3-diaminopropane | - |
Anisodus acutangulus |  |
| 1,3-diaminopropane | - |
Anisodus tanguticus | |
| 1,3-diaminopropane | - |
Atropa belladonna | |
| 1,3-diaminopropane | - |
Calystegia sepium | |
| 1,3-diaminopropane | - |
Capsicum annuum | |
| 1,3-diaminopropane | - |
Datura inoxia | |
| 1,3-diaminopropane | - |
Datura metel | |
| 1,3-diaminopropane | - |
Datura stramonium | |
| 1,3-diaminopropane | - |
Hyoscyamus niger | |
| 1,3-diaminopropane | - |
Ipomoea batatas | |
| 1,3-diaminopropane | - |
Nicotiana attenuata | |
| 1,3-diaminopropane | - |
Nicotiana benthamiana | |
| 1,3-diaminopropane | - |
Nicotiana sylvestris | |
| 1,3-diaminopropane | - |
Nicotiana tabacum | |
| 1,3-diaminopropane | - |
Physalis divaricata | |
| 1,3-diaminopropane | - |
Scopolia parviflora | |
| 1,3-diaminopropane | - |
Solanum dulcamara | |
| 1,3-diaminopropane | - |
Solanum lycopersicum | |
| 1,3-diaminopropane | - |
Solanum tuberosum | |
| cadaverine | - |
Anisodus acutangulus | |
| cadaverine | - |
Anisodus tanguticus | |
| cadaverine | - |
Atropa belladonna | |
| cadaverine | - |
Calystegia sepium | |
| cadaverine | - |
Capsicum annuum | |
| cadaverine | - |
Datura inoxia | |
| cadaverine | - |
Datura metel | |
| cadaverine | - |
Datura stramonium | |
| cadaverine | - |
Hyoscyamus niger | |
| cadaverine | - |
Ipomoea batatas | |
| cadaverine | - |
Nicotiana attenuata | |
| cadaverine | - |
Nicotiana benthamiana | |
| cadaverine | - |
Nicotiana sylvestris | |
| cadaverine | - |
Nicotiana tabacum | |
| cadaverine | - |
Physalis divaricata | |
| cadaverine | - |
Scopolia parviflora | |
| cadaverine | - |
Solanum dulcamara | |
| cadaverine | - |
Solanum lycopersicum | |
| cadaverine | - |
Solanum tuberosum | |
| n-butylamine | strong inhibitor; strong inhibitor | Anisodus acutangulus | |
| n-butylamine | strong inhibitor | Anisodus tanguticus | |
| n-butylamine | strong inhibitor; strong inhibitor | Atropa belladonna | |
| n-butylamine | strong inhibitor | Calystegia sepium | |
| n-butylamine | strong inhibitor | Capsicum annuum | |
| n-butylamine | strong inhibitor; strong inhibitor | Datura inoxia | |
| n-butylamine | strong inhibitor | Datura metel | |
| n-butylamine | strong inhibitor | Datura stramonium | |
| n-butylamine | strong inhibitor | Hyoscyamus niger | |
| n-butylamine | strong inhibitor | Ipomoea batatas | |
| n-butylamine | strong inhibitor; strong inhibitor | Nicotiana attenuata | |
| n-butylamine | strong inhibitor | Nicotiana benthamiana | |
| n-butylamine | strong inhibitor; strong inhibitor | Nicotiana sylvestris | |
| n-butylamine | strong inhibitor; strong inhibitor; strong inhibitor; strong inhibitor | Nicotiana tabacum | |
| n-butylamine | strong inhibitor | Physalis divaricata | |
| n-butylamine | strong inhibitor | Scopolia parviflora | |
| n-butylamine | strong inhibitor | Solanum dulcamara | |
| n-butylamine | strong inhibitor | Solanum lycopersicum | |
| n-butylamine | strong inhibitor | Solanum tuberosum | |
| N-methyl-1,3-diaminopropane | - |
Anisodus acutangulus | |
| N-methyl-1,3-diaminopropane | - |
Anisodus tanguticus | |
| N-methyl-1,3-diaminopropane | - |
Atropa belladonna | |
| N-methyl-1,3-diaminopropane | - |
Calystegia sepium | |
| N-methyl-1,3-diaminopropane | - |
Capsicum annuum | |
| N-methyl-1,3-diaminopropane | - |
Datura inoxia | |
| N-methyl-1,3-diaminopropane | - |
Datura metel | |
| N-methyl-1,3-diaminopropane | - |
Datura stramonium | |
| N-methyl-1,3-diaminopropane | - |
Hyoscyamus niger | |
| N-methyl-1,3-diaminopropane | - |
Ipomoea batatas | |
| N-methyl-1,3-diaminopropane | - |
Nicotiana attenuata | |
| N-methyl-1,3-diaminopropane | - |
Nicotiana benthamiana | |
| N-methyl-1,3-diaminopropane | - |
Nicotiana sylvestris | |
| N-methyl-1,3-diaminopropane | - |
Nicotiana tabacum | |
| N-methyl-1,3-diaminopropane | - |
Physalis divaricata | |
| N-methyl-1,3-diaminopropane | - |
Scopolia parviflora | |
| N-methyl-1,3-diaminopropane | - |
Solanum dulcamara | |
| N-methyl-1,3-diaminopropane | - |
Solanum lycopersicum | |
| N-methyl-1,3-diaminopropane | - |
Solanum tuberosum | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine | Anisodus acutangulus | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Anisodus tanguticus | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine | Atropa belladonna | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Calystegia sepium | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Capsicum annuum | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine | Datura inoxia | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Datura metel | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Datura stramonium | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Hyoscyamus niger | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Ipomoea batatas | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine | Nicotiana attenuata | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Nicotiana benthamiana | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine | Nicotiana sylvestris | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine | Nicotiana tabacum | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Physalis divaricata | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Scopolia parviflora | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Solanum dulcamara | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Solanum lycopersicum | |
| N-methylputrescine | inhibitor with approximately competitive interaction kinetics to putrescine | Solanum tuberosum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.042 | - |
S-adenosyl-L-methionine | - |
Datura stramonium | |
| 0.1 | - |
S-adenosyl-L-methionine | - |
Datura stramonium | |
| 0.108 | - |
putrescine | - |
Datura stramonium | |
| 0.12 | - |
putrescine | isoform PMT1 | Calystegia sepium | |
| 0.169 | - |
putrescine | - |
Solanum dulcamara | |
| 0.242 | - |
putrescine | - |
Solanum tuberosum | |
| 0.3 | - |
putrescine | - |
Datura stramonium | |
| 0.31 | - |
putrescine | - |
Datura stramonium | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anisodus acutangulus | B4YSH2 | - |
- |
| Anisodus acutangulus | B4YSH3 | - |
- |
| Anisodus tanguticus | Q68HB1 | - |
- |
| Atropa belladonna | Q9S7W8 | - |
- |
| Atropa belladonna | Q9XJ42 | - |
- |
| Calystegia sepium | Q2KTH3 | - |
- |
| Capsicum annuum | - |
- |
- |
| Datura inoxia | Q2KTH1 | - |
- |
| Datura inoxia | Q2KTH2 | - |
- |
| Datura metel | A0PFY1 | - |
- |
| Datura stramonium | Q70EW6 | - |
- |
| Hyoscyamus niger | Q9XJ41 | - |
- |
| Ipomoea batatas | - |
- |
- |
| Nicotiana attenuata | Q93XQ4 | - |
- |
| Nicotiana attenuata | Q93XQ5 | - |
- |
| Nicotiana benthamiana | B1NYI5 | - |
- |
| Nicotiana sylvestris | Q9ZWT7 | - |
- |
| Nicotiana sylvestris | Q9ZWT9 | - |
- |
| Nicotiana tabacum | Q42963 | - |
- |
| Nicotiana tabacum | Q9SEH4 | - |
- |
| Nicotiana tabacum | Q9SEH5 | - |
- |
| Nicotiana tabacum | Q9SEH7 | - |
- |
| Physalis divaricata | Q2KTH0 | - |
- |
| Scopolia parviflora | Q4VQ73 | - |
- |
| Solanum dulcamara | B1VK31 | - |
- |
| Solanum lycopersicum | Q2KTH4 | - |
- |
| Solanum tuberosum | Q70AR0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Capsicum annuum | - |
| leaf | - |
Ipomoea batatas | - |
| leaf | - |
Atropa belladonna | - |
| leaf | - |
Hyoscyamus niger | - |
| leaf | - |
Nicotiana sylvestris | - |
| leaf | - |
Physalis divaricata | - |
| leaf | - |
Anisodus tanguticus | - |
| leaf | - |
Calystegia sepium | - |
| leaf | - |
Datura inoxia | - |
| leaf | - |
Datura stramonium | - |
| leaf | - |
Solanum lycopersicum | - |
| leaf | - |
Solanum tuberosum | - |
| leaf | - |
Datura metel | - |
| leaf | - |
Nicotiana attenuata | - |
| leaf | - |
Nicotiana benthamiana | - |
| leaf | - |
Nicotiana tabacum | - |
| leaf | - |
Scopolia parviflora | - |
| leaf | - |
Solanum dulcamara | - |
| leaf | - |
Anisodus acutangulus | - |
| root | - |
Capsicum annuum | - |
| root | - |
Ipomoea batatas | - |
| root | - |
Atropa belladonna | - |
| root | - |
Hyoscyamus niger | - |
| root | - |
Nicotiana sylvestris | - |
| root | - |
Physalis divaricata | - |
| root | - |
Anisodus tanguticus | - |
| root | - |
Calystegia sepium | - |
| root | - |
Datura inoxia | - |
| root | - |
Datura stramonium | - |
| root | - |
Solanum lycopersicum | - |
| root | - |
Solanum tuberosum | - |
| root | - |
Datura metel | - |
| root | - |
Nicotiana attenuata | - |
| root | - |
Nicotiana benthamiana | - |
| root | - |
Nicotiana tabacum | - |
| root | - |
Scopolia parviflora | - |
| root | - |
Solanum dulcamara | - |
| root | - |
Anisodus acutangulus | - |
| stem | - |
Capsicum annuum | - |
| stem | - |
Ipomoea batatas | - |
| stem | - |
Atropa belladonna | - |
| stem | - |
Hyoscyamus niger | - |
| stem | - |
Nicotiana sylvestris | - |
| stem | - |
Physalis divaricata | - |
| stem | - |
Anisodus tanguticus | - |
| stem | - |
Calystegia sepium | - |
| stem | - |
Datura inoxia | - |
| stem | - |
Datura stramonium | - |
| stem | - |
Solanum lycopersicum | - |
| stem | - |
Solanum tuberosum | - |
| stem | - |
Datura metel | - |
| stem | - |
Nicotiana attenuata | - |
| stem | - |
Nicotiana benthamiana | - |
| stem | - |
Nicotiana tabacum | - |
| stem | - |
Scopolia parviflora | - |
| stem | - |
Solanum dulcamara | - |
| stem | - |
Anisodus acutangulus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + putrescine | - |
Capsicum annuum | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Ipomoea batatas | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Atropa belladonna | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Hyoscyamus niger | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Nicotiana sylvestris | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Physalis divaricata | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Anisodus tanguticus | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Calystegia sepium | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Datura inoxia | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Datura stramonium | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Solanum lycopersicum | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Solanum tuberosum | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Datura metel | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Nicotiana attenuata | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Nicotiana benthamiana | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Nicotiana tabacum | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Scopolia parviflora | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Solanum dulcamara | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
| S-adenosyl-L-methionine + putrescine | - |
Anisodus acutangulus | S-adenosyl-L-homocysteine + N-methylputrescine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PMT | - |
Capsicum annuum |
| PMT | - |
Ipomoea batatas |
| PMT | - |
Hyoscyamus niger |
| PMT | - |
Physalis divaricata |
| PMT | - |
Anisodus tanguticus |
| PMT | - |
Datura stramonium |
| PMT | - |
Solanum lycopersicum |
| PMT | - |
Solanum tuberosum |
| PMT | - |
Datura metel |
| PMT | - |
Nicotiana benthamiana |
| PMT | - |
Scopolia parviflora |
| PMT | - |
Solanum dulcamara |
| PMT1 | isoform | Atropa belladonna |
| PMT1 | isoform | Nicotiana sylvestris |
| PMT1 | isoform | Calystegia sepium |
| PMT1 | isoform | Datura inoxia |
| PMT1 | isoform | Nicotiana attenuata |
| PMT1 | isoform | Nicotiana tabacum |
| PMT1 | isoform | Anisodus acutangulus |
| PMT2 | isoform | Atropa belladonna |
| PMT2 | isoform | Calystegia sepium |
| PMT2 | isoform | Datura inoxia |
| PMT2 | isoform | Nicotiana attenuata |
| PMT2 | isoform | Nicotiana tabacum |
| PMT2 | isoform | Anisodus acutangulus |
| PMT3 | isoform | Nicotiana sylvestris |
| PMT3 | isoform | Nicotiana tabacum |
| PMT4 | isoform | Nicotiana tabacum |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.047 | - |
putrescine | - |
Solanum dulcamara | |
| 0.086 | - |
putrescine | isoform PMT2 | Calystegia sepium | |
| 0.131 | - |
putrescine | - |
Solanum tuberosum | |
| 0.16 | - |
putrescine | isoform PMT1 | Calystegia sepium | |
| 0.198 | - |
putrescine | - |
Physalis divaricata | |
| 0.359 | - |
putrescine | isoform PMT2 | Datura inoxia | |
| 0.383 | - |
putrescine | isoform PMT1 | Datura inoxia | |
| 0.388 | - |
putrescine | - |
Datura stramonium | |
| 1.73 | - |
putrescine | - |
Datura stramonium | |
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Release 2023.1 (January 2023)
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