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Literature summary for 2.1.1.5 extracted from

  • Szegedi, S.S.; Castro, C.C.; Koutmos, M.; Garrow, T.A.
    Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase (2008), J. Biol. Chem., 283, 8939-8945.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
AdoMet weak inhibitor, at 2 mM: 24% inhibition Homo sapiens
AdoMet weak inhibitor, at 2.5 mM: 15% inhibition Mus musculus
dimethylglycine at 0.2 mM: 80% inhibition, at 2 mM: 97% inhibition; weak inhibitor, at 2 mM: 11% inhibition Homo sapiens
dimethylglycine at 0.25 mM: 64% inhibition, at 2.5 mM: 95% inhibition; weak inhibitor, at 2.5 mM: 19% inhibition Mus musculus
dimethylsulfonioacetate at 2 mM: 79% inhibition; weak inhibitor, at 2 mM: 20% inhibition Homo sapiens
dimethylsulfonioacetate at 0.25 mM: 29% inhibition, at 2.5 mM: 82% inhibition Mus musculus
dimethylsulfoniopropionate weak inhibitor, at 2 mM: 29% inhibition Homo sapiens
dimethylsulfoniopropionate weak inhibitor, at 2.5 mM: 11% inhibition; weak inhibitor, at 2.5 mM: 17% inhibition Mus musculus
methionine at 2 mM: 60% inhibition; weak inhibitor at 2 mM: 15% inhibition Homo sapiens
methionine at 2.5 mM: 38% inhibition; at 2.5 mM: 48% inhibition Mus musculus
S-(delta-carboxybutyl)-L-homocysteine at 0.05 mM: 97% inhibition, at 0.5 mM: total inhibition; weak inhibitor, at 0.5 mM: 26% inhibition Homo sapiens
S-(delta-carboxybutyl)-L-homocysteine at 0.025 mM: 22% inhibition, at 0.0625 mM: 36% inhibition, at 0.125 mM: 49% inhibition, at 0.5 mM: 81% inhibition; total inhibition Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.76
-
S-methyl-L-methionine
-
Mus musculus
0.94
-
S-methyl-L-methionine
-
Homo sapiens
2.2
-
betaine
-
Homo sapiens
3
-
S-methyl-L-methionine
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn BHMT-2 is a zinc metalloenzyme Mus musculus
Zn BHMT-2 is a zinc metalloenzyme Homo sapiens
Zn2+ BHMT is a zinc metalloenzyme Homo sapiens
Zn2+ BHMT-2 is a zinc metalloenzyme Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-homocysteine + betaine
-
Mus musculus L-methionine + dimethylglycine
-
?
L-homocysteine + betaine
-
Homo sapiens L-methionine + dimethylglycine
-
?
L-homocysteine + S-methyl-L-methionine
-
Mus musculus ?
-
?
L-homocysteine + S-methyl-L-methionine
-
Homo sapiens ?
-
?
L-homocysteine + S-methyl-L-methionine BHMT-2 uses S-methylmethionine as a methyl donor for the methylation of homocysteine. Unlike BHMT, BHMT-2 can not use betaine Homo sapiens ?
-
?
L-homocysteine + S-methylmethionine BHMT-2 uses S-methylmethionine as a methyl donor for the methylation of homocysteine. Unlike BHMT, BHMT-2 can not use betaine Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
betaine-homocysteine S-methyltransferase
-
Mus musculus
betaine-homocysteine S-methyltransferase
-
Homo sapiens
betaine-homocysteine S-methyltransferase-2
-
Mus musculus
betaine-homocysteine S-methyltransferase-2
-
Homo sapiens
BHMT
-
Mus musculus
BHMT
-
Homo sapiens
BHMT-2
-
Homo sapiens
BHMT2
-
Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
24
-
S-methyl-L-methionine
-
Homo sapiens
38
-
S-methyl-L-methionine
-
Homo sapiens
88
-
betaine
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus