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Literature summary for 2.1.1.47 extracted from
- S-Adenosylmethionine:indolepyruvate 3-methyltransferase (1975), Methods Enzymol., 43, 498-502.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Streptomyces griseus |  |
| 2,2'-bipyridyl | - |
Streptomyces griseus | |
| additional information | no inhibition by EDTA | Streptomyces griseus | |
| N-ethylmaleimide | - |
Streptomyces griseus | |
| p-chloromercuribenzoate | - |
Streptomyces griseus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0048 | - |
Indolepyruvate | - |
Streptomyces griseus | |
| 0.013 | - |
S-adenosyl-L-methionine | - |
Streptomyces griseus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Streptomyces griseus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
gel filtration | Streptomyces griseus |
| 58500 | - |
sucrose density gradient centrifugation | Streptomyces griseus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces griseus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces griseus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0083 | - |
- |
Streptomyces griseus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no substrates are phenylpyruvate, p-hydroxyphenylpyruvate | Streptomyces griseus | ? | - |
? | |
| S-adenosyl-L-methionine + indolepyruvate | - |
Streptomyces griseus | S-adenosyl-L-homocysteine + (S)-beta-methylindolepyruvate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
phosphate buffer | Streptomyces griseus |
| 7.5 | 8.5 | - |
Streptomyces griseus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
and below, irreversible inactivation | Streptomyces griseus |
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