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Literature summary for 2.1.1.45 extracted from

  • Wang, K.; Wang, Q.; Chen, J.; Chen, L.; Jiang, H.; Shen, X.
    Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1 (2011), Protein Sci., 20, 1398-1410.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.45

Inhibitors

Inhibitors Comment Organism Structure
10-methylfolate
-
 Helicobacter pylori
5-fluoro-2'-deoxyuridine monophosphate
-
 Helicobacter pylori
8-azapurinone deoxyribonucleoside 5'-phosphate
-
 Helicobacter pylori
N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-ynoyl)amino}benzoyl)-L-glutamic acid
-
 Helicobacter pylori

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Helicobacter pylori SS1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
 Helicobacter pylori dihydrofolate + dTMP
-
 ?
5,10-methylenetetrahydrofolate + dUMP
-
 Helicobacter pylori SS1 dihydrofolate + dTMP
-
 ?

Synonyms

Synonyms Comment Organism
ThyA
-
 Helicobacter pylori
thymidylate synthase A
-
 Helicobacter pylori