Literature summary for 2.1.1.45 extracted from

Chatterjee, I.; Kriegeskorte, A.; Fischer, A.; Deiwick, S.; Theimann, N.; Proctor, R.; Peters, G.; Herrmann, M.; Kahl, B.
In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus (2008), J. Bacteriol., 190, 834-842.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Staphylococcus aureus

Protein Variants

Protein Variants	Comment	Organism
additional information	mutations of the thyA gene are responsible for the phenotype of trimethoprim-sulfamethoxazole-resistant thymidine-dependent small-colony variants of Staphylococcus aureus	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	wild type strain 8325-4 and trimethoprim-sulfamethoxazole-resistant thymidine-dependent small-colony variants 1-8	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	-	Staphylococcus aureus	dihydrofolate + dTMP	-	?

Synonyms

Synonyms	Comment	Organism
ThyA	-	Staphylococcus aureus

Cofactor

Cofactor	Comment	Organism	Structure
N5,N10-methylenetetrahydrofolate	-	Staphylococcus aureus

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Release 2023.1 (January 2023)