Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-deoxy-5-fluorouridine 5'-phosphate | - |
Trypanosoma brucei | |
pemetrexed | - |
Trypanosoma brucei | |
raltitrexed | - |
Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma brucei | dihydrofolate + dTMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHFRTS | - |
Trypanosoma brucei |
dihydrofolate reductase-thymidylate synthase | bifunctional enzyme | Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
N5,N10-methylenetetrahydrofolate | - |
Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
malfunction | growth of single-knockout lines of dihydrofolate reductase-thymidylate synthase in vitro are identical to wild type cells, whereas double-knockout lines of dihydrofolate reductase-thymidylate synthase have an absolute requirement for thymidine | Trypanosoma brucei |
physiological function | DHFRTS is essential for parasite survival | Trypanosoma brucei |