Cloned (Comment) | Organism |
---|---|
clone harbors the pO2CLSA-4 plasmid expressed in an Escherichia coli Rue 10 expression vector | Leishmania major |
Crystallization (Comment) | Organism |
---|---|
- |
Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-fluoro-2'-deoxyuridylic acid | - |
Escherichia coli | |
5-fluoro-2'-deoxyuridylic acid | - |
Leishmania major |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | Escherichia coli | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Leishmania major | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Toxoplasma gondii | - |
dihydrofolate + dTMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Leishmania major | - |
formerly called Leishmania tropica | - |
Toxoplasma gondii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6S)-tetrahydropteroylglutamate + 2-deoxyuridylate | - |
Leishmania major | 7,8-dihydropteroylglutamate + thymidine phosphate | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Leishmania major | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Leishmania major | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Toxoplasma gondii | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Toxoplasma gondii | dihydrofolate + dTMP | - |
r | |
additional information | - |
Escherichia coli | ? | - |
? | |
additional information | bifunctional enzyme dihydrofolate reductase-thymidylate synthase | Leishmania major | ? | - |
? | |
additional information | bifunctional enzyme dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.67 | - |
2'-deoxyuridine | - |
Leishmania major |