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Literature summary for 2.1.1.38 extracted from
- Biosynthesis of puromycin in Streptomyces alboniger: regulation and properties of O-demethylpuromycin O-methyltransferase (1975), Antimicrob. Agents Chemother., 8, 721-732.
General Stability
| General Stability | Organism |
|---|---|
| stabilized by addition of S-adenosyl-L-methionine | Streptomyces alboniger |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-glucose | reduced enzyme form, represses puromycin synthesis | Streptomyces alboniger |  |
| puromycin | - |
Streptomyces alboniger | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + O-demethylpuromycin | Streptomyces alboniger | - |
S-adenosyl-L-homocysteine + puromycin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces alboniger | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces alboniger |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + O-demethylpuromycin | - |
Streptomyces alboniger | S-adenosyl-L-homocysteine + puromycin | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
rapidly inactivated at 37°C, very unstable even at low temperatures, enzyme activity is destroyed upon boiling | Streptomyces alboniger |
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