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Literature summary for 2.1.1.379 extracted from

  • Deobald, D.; Adrian, L.; Schöne, C.; Rother, M.; Layer, G.
    Identification of a unique Radical SAM methyltransferase required for the sp3-C-methylation of an arginine residue of methyl-coenzyme M reductase (2018), Sci. Rep., 8, 7404 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + a [methyl coenzyme-M reductase]-L-arginine285 + reduced acceptor Methanosarcina acetivorans
-
 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a [methyl coenzyme-M reductase]-(5S)-C-methyl-L-arginine285 + acceptor
-
 ?
2 S-adenosyl-L-methionine + a [methyl coenzyme-M reductase]-L-arginine285 + reduced acceptor Methanosarcina acetivorans DSM 2834
-
 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a [methyl coenzyme-M reductase]-(5S)-C-methyl-L-arginine285 + acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Methanosarcina acetivorans Q8THG6
-
-
Methanosarcina acetivorans DSM 2834 Q8THG6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + a [methyl coenzyme-M reductase]-L-arginine285 + reduced acceptor
-
 Methanosarcina acetivorans S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a [methyl coenzyme-M reductase]-(5S)-C-methyl-L-arginine285 + acceptor
-
 ?
2 S-adenosyl-L-methionine + a [methyl coenzyme-M reductase]-L-arginine285 + reduced acceptor
-
 Methanosarcina acetivorans DSM 2834 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a [methyl coenzyme-M reductase]-(5S)-C-methyl-L-arginine285 + acceptor
-
 ?

Synonyms

Synonyms Comment Organism
MA4551
-
 Methanosarcina acetivorans
methanogenesis marker 10
-
 Methanosarcina acetivorans

General Information

General Information Comment Organism
malfunction enzyme knockout strains show impaired growth under stress conditions such as the presence of 0.2 mM hydrogen peroxide or elevated temperature (42°C) Methanosarcina acetivorans