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Literature summary for 2.1.1.374 extracted from

  • Sartor, P.; Bock, J.; Hennecke, U.; Thierbach, S.; Fetzner, S.
    Modification of the Pseudomonasxa0aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4(1H)-one and other secondary metabolites by methyltransferases from mycobacteria (2020), FEBS J., 288, 2360-2376.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0094
-
2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacterium tuberculosis
0.0098
-
2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacteroides abscessus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one Mycobacteroides abscessus
-
S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one Mycobacterium tuberculosis
-
S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one Mycobacteroides abscessus ATCC 19977
-
S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one Mycobacterium tuberculosis ATCC 25618
-
S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WKL5
-
-
Mycobacterium tuberculosis ATCC 25618 P9WKL5
-
-
Mycobacteroides abscessus B1MCE2
-
-
Mycobacteroides abscessus ATCC 19977 B1MCE2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one
-
Mycobacteroides abscessus S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one
-
Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one preferred substrate Mycobacteroides abscessus S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one preferred substrate Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one
-
Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one preferred substrate Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one
-
Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one preferred substrate Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one
-
Mycobacteroides abscessus S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one
-
Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one
-
Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one
-
Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one
-
?
S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one
-
Mycobacteroides abscessus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one
-
Mycobacterium tuberculosis S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one
-
Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one
-
Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + 4-hydroxyisoquinolin-1(2H)-one
-
Mycobacteroides abscessus S-adenosyl-L-homocysteine + 4-methoxyisoquinolin-1(2H)-one
-
?
S-adenosyl-L-methionine + 4-hydroxyisoquinolin-1(2H)-one
-
Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 4-methoxyisoquinolin-1(2H)-one
-
?
S-adenosyl-L-methionine + 4-hydroxyquinolin-2(1H)-one
-
Mycobacteroides abscessus S-adenosyl-L-homocysteine + 4-methoxyquinolin-2(1H)-one
-
?
S-adenosyl-L-methionine + 4-hydroxyquinolin-2(1H)-one
-
Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 4-methoxyquinolin-2(1H)-one
-
?
S-adenosyl-L-methionine + quercetin methylation sites not assigned Mycobacteroides abscessus S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + quercetin methylation sites not assigned Mycobacterium tuberculosis S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + quercetin methylation sites not assigned Mycobacteroides abscessus ATCC 19977 S-adenosyl-L-homocysteine + ?
-
?
S-adenosyl-L-methionine + quercetin methylation sites not assigned Mycobacterium tuberculosis ATCC 25618 S-adenosyl-L-homocysteine + ?
-
?

Synonyms

Synonyms Comment Organism
HQNO O-methyltransferase
-
Mycobacteroides abscessus
HQNO O-methyltransferase
-
Mycobacterium tuberculosis
MAB_2834c
-
Mycobacteroides abscessus
rv0560c
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mycobacteroides abscessus
30
-
assay at Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.09
-
2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacteroides abscessus
0.09
-
2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Mycobacteroides abscessus
7
-
assay at Mycobacterium tuberculosis

General Information

General Information Comment Organism
drug target the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs.Synthetic antimycobacterial agents may be designed to be unamenable to methyl transfer Mycobacteroides abscessus
drug target the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs.Synthetic antimycobacterial agents may be designed to be unamenable to methyl transfer Mycobacterium tuberculosis
physiological function the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs Mycobacteroides abscessus
physiological function the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs Mycobacterium tuberculosis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
85.1
-
2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacterium tuberculosis
204.1
-
2-heptyl-1-hydroxyquinolin-4(1H)-one pH 7.0 30°C Mycobacteroides abscessus