KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0094 | - |
2-heptyl-1-hydroxyquinolin-4(1H)-one | pH 7.0 30°C | Mycobacterium tuberculosis | |
0.0098 | - |
2-heptyl-1-hydroxyquinolin-4(1H)-one | pH 7.0 30°C | Mycobacteroides abscessus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | Mycobacteroides abscessus | - |
S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | Mycobacterium tuberculosis | - |
S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | Mycobacteroides abscessus ATCC 19977 | - |
S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | Mycobacterium tuberculosis ATCC 25618 | - |
S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WKL5 | - |
- |
Mycobacterium tuberculosis ATCC 25618 | P9WKL5 | - |
- |
Mycobacteroides abscessus | B1MCE2 | - |
- |
Mycobacteroides abscessus ATCC 19977 | B1MCE2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | - |
Mycobacteroides abscessus | S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | - |
Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | preferred substrate | Mycobacteroides abscessus | S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | preferred substrate | Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | - |
Mycobacteroides abscessus ATCC 19977 | S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | preferred substrate | Mycobacteroides abscessus ATCC 19977 | S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | - |
Mycobacterium tuberculosis ATCC 25618 | S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one | preferred substrate | Mycobacterium tuberculosis ATCC 25618 | S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one | - |
Mycobacteroides abscessus | S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one | - |
Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one | - |
Mycobacteroides abscessus ATCC 19977 | S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptyl-3-hydroxyquinolin-4(1H)-one | - |
Mycobacterium tuberculosis ATCC 25618 | S-adenosyl-L-homocysteine + 2-heptyl-3-methoxyquinolin-4(1H)-one | - |
? | |
S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one | - |
Mycobacteroides abscessus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one | - |
Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one | - |
Mycobacteroides abscessus ATCC 19977 | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + 2-heptylquinolin-4(1H)-one | - |
Mycobacterium tuberculosis ATCC 25618 | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + 4-hydroxyisoquinolin-1(2H)-one | - |
Mycobacteroides abscessus | S-adenosyl-L-homocysteine + 4-methoxyisoquinolin-1(2H)-one | - |
? | |
S-adenosyl-L-methionine + 4-hydroxyisoquinolin-1(2H)-one | - |
Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + 4-methoxyisoquinolin-1(2H)-one | - |
? | |
S-adenosyl-L-methionine + 4-hydroxyquinolin-2(1H)-one | - |
Mycobacteroides abscessus | S-adenosyl-L-homocysteine + 4-methoxyquinolin-2(1H)-one | - |
? | |
S-adenosyl-L-methionine + 4-hydroxyquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + 4-methoxyquinolin-2(1H)-one | - |
? | |
S-adenosyl-L-methionine + quercetin | methylation sites not assigned | Mycobacteroides abscessus | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + quercetin | methylation sites not assigned | Mycobacterium tuberculosis | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + quercetin | methylation sites not assigned | Mycobacteroides abscessus ATCC 19977 | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + quercetin | methylation sites not assigned | Mycobacterium tuberculosis ATCC 25618 | S-adenosyl-L-homocysteine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HQNO O-methyltransferase | - |
Mycobacteroides abscessus |
HQNO O-methyltransferase | - |
Mycobacterium tuberculosis |
MAB_2834c | - |
Mycobacteroides abscessus |
rv0560c | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mycobacteroides abscessus |
30 | - |
assay at | Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.09 | - |
2-heptyl-1-hydroxyquinolin-4(1H)-one | pH 7.0 30°C | Mycobacteroides abscessus | |
0.09 | - |
2-heptyl-1-hydroxyquinolin-4(1H)-one | pH 7.0 30°C | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mycobacteroides abscessus |
7 | - |
assay at | Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs.Synthetic antimycobacterial agents may be designed to be unamenable to methyl transfer | Mycobacteroides abscessus |
drug target | the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs.Synthetic antimycobacterial agents may be designed to be unamenable to methyl transfer | Mycobacterium tuberculosis |
physiological function | the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs | Mycobacteroides abscessus |
physiological function | the enzyme is involved in cellular response to chemical stress and possibly contributes to resistance of mycobacteria toward antimicrobial natural compounds as well as drugs | Mycobacterium tuberculosis |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
85.1 | - |
2-heptyl-1-hydroxyquinolin-4(1H)-one | pH 7.0 30°C | Mycobacterium tuberculosis | |
204.1 | - |
2-heptyl-1-hydroxyquinolin-4(1H)-one | pH 7.0 30°C | Mycobacteroides abscessus |