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Literature summary for 2.1.1.370 extracted from

  • Kim, S.M.; Kee, H.J.; Eom, G.H.; Choe, N.W.; Kim, J.Y.; Kim, Y.S.; Kim, S.K.; Kook, H.; Kook, H.; Seo, S.B.
    Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity (2006), Biochem. Biophys. Res. Commun., 345, 318-323 .
    View publication on PubMed

Application

Application Comment Organism
medicine Nsd3 expression is increased in both acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL) patients Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [histone H3]-L-lysine4 Homo sapiens
-
S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine4
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine4 Homo sapiens
-
S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine4
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZ95
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Nsd3 is specific for the histones H3K4 and H3K27 residues Homo sapiens ?
-
-
S-adenosyl-L-methionine + [histone H3]-L-lysine4
-
Homo sapiens S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine4
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine4
-
Homo sapiens S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine4
-
?

Synonyms

Synonyms Comment Organism
NSD3
-
Homo sapiens
WHISTLE
-
Homo sapiens
WHSC1L1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function Nsd3 dimethylates H3K4 and additionally di-, and tri-methylates histones H3K27. Overexpression of Nsd3 represses transcription of the SV40 promoter Homo sapiens