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Literature summary for 2.1.1.37 extracted from

  • Lukinavicius, G.; Lapinaite, A.; Urbanaviciute, G.; Gerasimaite, R.; Klimasauskas, S.
    Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA (2012), Nucleic Acids Res., 40, 11594-11602.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
structure-based model of the M.HhaI-DNA-cofactor complex. Residues Gln82, Tyr254 and Asn304 are in close proximity and thus might sterically interfere with the extended transferable side chains Haemophilus parahaemolyticus

Protein Variants

Protein Variants Comment Organism
N304A 4fold improved activity with S-adenosyl-L-methionine analog containing a S-butynyl group, 5fold improved actitivity with S-adenosyl-L-methionine analog containing a S-pentynyl group Haemophilus parahaemolyticus
Q82A 4fold improved activity with S-adenosyl-L-methionine analog containing a S-butynyl group, 16fold decrease in activity with S-adenosyl-L-methionine Haemophilus parahaemolyticus
Q82A/N304A no further improvement of activity compared to single mutants Haemophilus parahaemolyticus
Q82A/Y254S/N304A significantly improved actitivity with S-adenosyl-L-methionine analogs containing a S-butynyl, a S-pentynyl or a S-6-(4-aminobutanamido)hex-2-yn-1-yl group Haemophilus parahaemolyticus
Y254S significantly improved actitivity with S-adenosyl-L-methionine analogs containing a S-butynyl or a S-pentynyl group Haemophilus parahaemolyticus
Y254S/N304A significantly improved actitivity with S-adenosyl-L-methionine analogs containing a S-butynyl, a S-pentynyl or a S-6-(4-aminobutanamido)hex-2-yn-1-yl group Haemophilus parahaemolyticus

Organism

Organism UniProt Comment Textmining
Haemophilus parahaemolyticus P05102
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Synonyms

Synonyms Comment Organism
hhaIM
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Haemophilus parahaemolyticus
M.HhaI
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Haemophilus parahaemolyticus