Literature summary for 2.1.1.37 extracted from

Cohen, H.M.; Griffiths, A.D.; Tawfik, D.S.; Loakes, D.
Determinants of cofactor binding to DNA methyltransferases: insights from a systematic series of structural variants of S-adenosylhomocysteine (2005), Org. Biomol. Chem., 3, 152-161.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5'-(3-aminopropylthio)-5'-deoxyadenosine	-	Haemophilus aegyptius
5'-(3-aminopropylthio)-5'-deoxyadenosine	-	Haemophilus parahaemolyticus
5'-(3-carboxypropylthio)-5'-deoxyadenosine	-	Haemophilus aegyptius
5'-(3-carboxypropylthio)-5'-deoxyadenosine	-	Haemophilus parahaemolyticus
S-(2'-deoxy-b -D-ribofuranosyladenosin-5'-yl)-L-homocysteine	-	Haemophilus aegyptius
S-(2'-deoxy-beta-D-ribofuranosyladenosin-5'-yl)-L-homocysteine	-	Haemophilus parahaemolyticus
S-(N6 -benzoyladenosin-5'-yl)-L-homocysteine	-	Haemophilus parahaemolyticus
S-(N6-benzoyladenosin-5'-yl)-L-homocysteine	-	Haemophilus aegyptius
S-adenosin-5'-yl-L-homocysteine methylamide	-	Haemophilus aegyptius
S-adenosin-5'-yl-L-homocysteine methylamide	-	Haemophilus parahaemolyticus
S-adenosyl-L-homocysteine	-	Haemophilus aegyptius
S-adenosyl-L-homocysteine	-	Haemophilus parahaemolyticus
S-cytid-5'-yl-L-homocysteine	-	Haemophilus aegyptius
S-cytid-5'-yl-L-homocysteine	-	Haemophilus parahaemolyticus
S-inosin-5'-yl-L-homocysteine	-	Haemophilus aegyptius
S-inosin-5'-yl-L-homocysteine	-	Haemophilus parahaemolyticus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0000037	-	unmethylated 30-mer DNA containing cytosine	pH 8.5, 37°C	Haemophilus aegyptius
0.000004	-	unmethylated 30-mer DNA containing cytosine	pH 7.5, 37°C	Haemophilus parahaemolyticus
0.00011	-	S-adenosyl-L-methionine	pH 7.5, 37°C	Haemophilus parahaemolyticus
0.00028	-	S-adenosyl-L-methionine	pH 8.5, 37°C	Haemophilus aegyptius

Organism

Organism	UniProt	Comment	Textmining
Haemophilus aegyptius	P20589	-	-
Haemophilus parahaemolyticus	P05102	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + DNA	-	Haemophilus parahaemolyticus	S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine	-	?
S-adenosyl-L-methionine + DNA	-	Haemophilus aegyptius	S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine	-	?
S-adenosyl-L-methionine + unmethylated 30-mer DNA containing cytosine	-	Haemophilus parahaemolyticus	S-adenosyl-L-homocysteine + unmethylated 30-mer DNA containing 5-methylcytosine	-	?
S-adenosyl-L-methionine + unmethylated 30-mer DNA containing cytosine	-	Haemophilus aegyptius	S-adenosyl-L-homocysteine + unmethylated 30-mer DNA containing 5-methylcytosine	-	?

Synonyms

Synonyms	Comment	Organism
M.HhaI	-	Haemophilus parahaemolyticus
M.HhaIII	-	Haemophilus aegyptius

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.0068	-	S-adenosyl-L-methionine	pH 8.5, 37°C	Haemophilus aegyptius
0.0068	-	unmethylated 30-mer DNA containing cytosine	pH 8.5, 37°C	Haemophilus aegyptius

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000015	-	S-adenosyl-L-homocysteine	-	Haemophilus parahaemolyticus
0.000069	-	S-adenosyl-L-homocysteine	pH 8.5, 37°C	Haemophilus aegyptius
0.0081	-	S-(N6 -benzoyladenosin-5'-yl)-L-homocysteine	-	Haemophilus parahaemolyticus
0.013	-	5'-(3-carboxypropylthio)-5'-deoxyadenosine	-	Haemophilus parahaemolyticus
0.016	-	5'-(3-aminopropylthio)-5'-deoxyadenosine	-	Haemophilus parahaemolyticus
0.027	-	S-cytid-5'-yl-L-homocysteine	-	Haemophilus parahaemolyticus
0.032	-	S-(N6 -benzoyladenosin-5'-yl)-L-homocysteine	pH 8.5, 37°C	Haemophilus aegyptius
0.037	-	5'-(3-aminopropylthio)-5'-deoxyadenosine	pH 8.5, 37°C	Haemophilus aegyptius
0.044	-	S-(2'-deoxy-b -D-ribofuranosyladenosin-5'-yl)-L-homocysteine	-	Haemophilus parahaemolyticus
0.059	-	S-adenosin-5'-yl-L-homocysteine methylamide	-	Haemophilus parahaemolyticus
0.069	-	S-(2'-deoxy-b -D-ribofuranosyladenosin-5'-yl)-L-homocysteine	pH 8.5, 37°C	Haemophilus aegyptius
0.23	-	5'-(3-carboxypropylthio)-5'-deoxyadenosine	pH 8.5, 37°C	Haemophilus aegyptius
0.29	-	S-adenosin-5'-yl-L-homocysteine methylamide	pH 8.5, 37°C	Haemophilus aegyptius

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Release 2023.1 (January 2023)