Literature summary for 2.1.1.37 extracted from

Geiman, T.M.; Sankpal, U.T.; Robertson, A.K.; Chen, Y.; Mazumdar, M.; Heale, J.T.; Schmiesing, J.A.; Kim, W.; Yokomori, K.; Zhao, Y.; Robertson, K.D.
Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery (2004), Nucleic Acids Res., 32, 2716-2729.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + DNA	Homo sapiens	DNMT3B interacts with several components of the condensin complex (hCAP-C,hCAP-E and hCAP-G) and KIF4A. Condensin mediates genome-wide chromosome condensation at the onset of mitosis and is critical for proper segregation of sister chromatids. KIF4A is proposed to be a motor protein carrying DNA as cargo. DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A and the ATP-dependent chromatin remodeling enzyme hSNF2H. DNMT3B co-localizes with condensin and KIF4A on condensed chromosomes throughout mitosis, direct link between the machineries regulating DNA methylation and mitotic chromosome condensation. DNMT3B may have a previously unrecognized function during the mitotic phase of the cell cycle	S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UBC3	-	-

Purification (Commentary)

Purification (Comment)	Organism
DNMT3B copurifies with several components of the condensin complex and KIF4A	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + DNA	DNMT3B interacts with several components of the condensin complex (hCAP-C,hCAP-E and hCAP-G) and KIF4A. Condensin mediates genome-wide chromosome condensation at the onset of mitosis and is critical for proper segregation of sister chromatids. KIF4A is proposed to be a motor protein carrying DNA as cargo. DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A and the ATP-dependent chromatin remodeling enzyme hSNF2H. DNMT3B co-localizes with condensin and KIF4A on condensed chromosomes throughout mitosis, direct link between the machineries regulating DNA methylation and mitotic chromosome condensation. DNMT3B may have a previously unrecognized function during the mitotic phase of the cell cycle	Homo sapiens	S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine	-	?

Synonyms

Synonyms	Comment	Organism
DNA methyltransferase	-	Homo sapiens
DNMT3B	-	Homo sapiens

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Release 2023.1 (January 2023)