Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | - |
Homo sapiens | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
S-adenosyl-L-methionine + DNA | methylation of a series of snapback oligodeoxynucleotides of differing stem length, each containing a centrally located CG dinucleotide recognition site. The enzyme requires a minimum of 22 base pairs in the stem for maximum activity. Extrahelical cytosines in slipped duplexes that are 30 base pairs in length act as effective methyl acceptors and are more rapidly methylated than cytosines that are Watson-Crick paired. Duplexes containing hairpins of CCG repeats in cruciform structures in which the enzyme recognition sequence is disrupted by a C-C mispair are also more rapidly methylated than the control Watson-Crick-paired duplexes | Homo sapiens | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |