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Literature summary for 2.1.1.369 extracted from

  • Jacob, Y.; Feng, S.; LeBlanc, C.A.; Bernatavichute, Y.V.; Stroud, H.; Cokus, S.; Johnson, L.M.; Pellegrini, M.; Jacobsen, S.E.;Michaels, S.D.
    ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing (2009), Nat. Struct. Mol. Biol., 16, 763-768 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [histone H3]-L-lysine27 Arabidopsis thaliana
-
 S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8VZJ1
-
-
Arabidopsis thaliana Q9FNE9 isoform Atxr6
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoforms Atxr5 and Atxr6 specifically monomethylate histone H3K27 Arabidopsis thaliana ?
-
-
S-adenosyl-L-methionine + [histone H3]-L-lysine27
-
 Arabidopsis thaliana S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27
-
 ?

Synonyms

Synonyms Comment Organism
ATXR5
-
 Arabidopsis thaliana
Atxr6
-
 Arabidopsis thaliana
trithorax-related protein 5
-
 Arabidopsis thaliana
trithorax-related protein 6
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function isoforms ATXR5 and ATXR6 exhibit histone H3K27 monomethyltransferase activity and double mutants have reduced H3K27me1 levels in vivo and show partial heterochromatin decondensation. Mutations in Atxr5 and Atxr6 also lead to transcriptional activation of repressed heterochromatic elements. H3K9me2 and DNA methylation are unaffected in the double mutant Arabidopsis thaliana