Literature summary for 2.1.1.361 extracted from

Liao, T.; Wang, Y.J.; Hu, J.Q.; Wang, Y.; Han, L.T.; Ma, B.; Shi, R.L.; Qu, N.; Wei, W.J.; Guan, Q.; Xiang, J.; Chen, J.Y.; Sun, G.H.; Li, D.S.; Mu, X.M.; Ji, Q.H.
Histone methyltransferase KMT5A gene modulates oncogenesis and lipid metabolism of papillary thyroid cancer in vitro (2018), Oncol. Rep., 39, 2185-2192 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20	Homo sapiens	-	S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NQR1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
papillary thyroid cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20	-	Homo sapiens	S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20	-	?

Synonyms

Synonyms	Comment	Organism
KMT5a	-	Homo sapiens
PR-Set7/9	-	Homo sapiens
SET8	-	Homo sapiens
SETD8	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme expression is upregulated in papillary thyroid carcinoma tissue	up

General Information

General Information	Comment	Organism
malfunction	enzyme inhibition attenuates proliferation and induces apoptosis. Cell migration and invasion are suppressed in enzyme-knockdown cells. Enzyme inhibition arrests the cell cycle in the G1/S phase of papillary thyroid cancer cells. Enzyme inhibition suppresses the expression of SREBP1, SCD, FASN and ACC, key molecules involved in lipid metabolism and decreases the level of malondialdehyde in papillary thyroid cancer cells	Homo sapiens
physiological function	the enzyme is an oncogenic factor, specifically a regulator for lipid metabolism in papillary thyroid carcinoma	Homo sapiens

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Release 2023.1 (January 2023)