Protein Variants | Comment | Organism |
---|---|---|
R179A/K180A | the mutations lead to similar enzymatic activity as the wild type equivalent and about 2.5fold decrease in nucleosome binding affinity | Homo sapiens |
R179A/K180A/R188A/R189A | the mutations produce similar enzymatic activity and even weaker nucleosome binding as compared to the R188A/R189A mutant | Homo sapiens |
R188A/R189A | the mutant has reduced nucleosome methyltransferase and much lower nucleosome binding activity (56% of full length, wild type enzyme activity, and 0.0025 mM nucleosome binding dissociation constant or over 300fold lower binding affinity compared to the equivalent wild type protein) | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme binding to the nucleosome protects it from degradation during the cell cycle. Full length enzyme has 3.8% of its histone methyltransferase activity on nucleosomes containing the H2A/E61A/ E64A/D90A/E92A mutations compared to wild type nucleosomes | ? | - |
? | |
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme binding to the nucleosome protects it from degradation during the cell cycle. Full length enzyme has 3.8% of its histone methyltransferase activity on nucleosomes containing the H2A/E61A/ E64A/D90A/E92A mutations compared to wild type nucleosomes | Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SET8 | - |
Homo sapiens |