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Literature summary for 2.1.1.361 extracted from

  • Kapoor-Vazirani, P.; Vertino, P.M.
    A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing (2014), J. Biol. Chem., 289, 7425-7437 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NQR1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Synonyms

Synonyms Comment Organism
Pr-Set7
-
 Homo sapiens
SETD8
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme controls both histone H4 lysine 16 acetylation and histone H4 lysine 20 trimethylation and in doing so, regulates RNA polymerase II pausing dynamics. Enzyme-mediated histone H4 lysine 20 monomethylation is necessary for the recruitment of the male-specific lethal complex, subsequent histone H4 lysine 16 acetylation, and release of RNA polymerase II into active elongation Homo sapiens