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Literature summary for 2.1.1.361 extracted from

  • Houston, S.I.; McManus, K.J.; Adams, M.M.; Sims, J.K.; Carpenter, P.B.; Hendzel, M.J.; Rice, J.C.
    Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability (2008), J. Biol. Chem., 283, 19478-19488 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.361

Protein Variants

Protein Variants Comment Organism
R265G inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NQR1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Synonyms

Synonyms Comment Organism
histone H4 lysine 20 monomethyltransferase
-
 Homo sapiens
Pr-Set7
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme depletion results in decondensed chromosomes and centrosome amplification Homo sapiens
physiological function the enzyme activity is essential for cell cycle progression, mitotic entry and genomic stability Homo sapiens