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Literature summary for 2.1.1.361 extracted from

  • Tanaka, H.; Takebayashi, S.I.; Sakamoto, A.; Igata, T.; Nakatsu, Y.; Saitoh, N.; Hino, S.; Nakao, M.
    The SETD8/PR-Set7 methyltransferase functions as a barrier to prevent senescence-associated metabolic remodeling (2017), Cell Rep., 18, 2148-2161 .
    View publication on PubMed
Search for more literature for 2.1.1.361

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NQR1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
IMR-90 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Pr-Set7
-
 Homo sapiens
SETD8
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is downregulated in senescent cells down

General Information

General Information Comment Organism
malfunction enzyme loss triggers cellular senescence Homo sapiens
physiological function the enzyme functions as a barrier to prevent senescence-associated metabolic remodeling. The enzyme represses senescence-associated genes including ribosomal proteins, ribosomal RNAs, and p16INK4A by catalyzing mono-methylation of histone H4 at lysine 20 Homo sapiens