Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.360 extracted from

  • Farooq, Z.; Banday, S.; Pandita, T.; Altaf, M.
    The many faces of histone H3K79 methylation (2016), Mutat. Res. Rev. Mutat. Res., 768, 46-52 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.360

Inhibitors

Inhibitors Comment Organism Structure
EPZ004777
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-
nucleus
-
 Saccharomyces cerevisiae 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Saccharomyces cerevisiae overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TEK3
-
-
Saccharomyces cerevisiae Q04089
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 overall reaction Saccharomyces cerevisiae 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Synonyms

Synonyms Comment Organism
Dot1
-
 Saccharomyces cerevisiae
Dot1-like protein
-
 Homo sapiens
DOT1L
-
 Homo sapiens
KMT4
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function enzyme-mediated methylation of [histone H3]-L-lysine79 is involved in the regulation of telomeric silencing, cell-cycle regulation, transcription elongation, DNA repair, cardiac function, embryonic development, erythropoiesis, and leukemia. Enzyme-mediated methylation of histone H3 lysine79 on the HOXA9 promoter contributes to increased expression of Hoxa9 in acute myeloid leukemia Homo sapiens