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Literature summary for 2.1.1.360 extracted from

  • Kuntimaddi, A.; Achille, N.J.; Thorpe, J.; Lokken, A.A.; Singh, R.; Hemenway, C.S.; Adli, M.; Zeleznik-Le, N.J.; Bushweller, J.H.
    Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 di- and tri-methylation on target genes and transformation potential (2015), Cell Rep., 11, 808-820 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.360

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TEK3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Synonyms

Synonyms Comment Organism
DOT1L
-
 Homo sapiens
histone 3 lysine 79 methyltransferase (H3K79me1/me2/me3)
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is required for mixed lineage leukemia-AF9 (MLL-AF9) leukemogenesis. The degree of enzyme recruitment to MLL-AF9 defines the level of hematopoietic transformation Homo sapiens