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Literature summary for 2.1.1.360 extracted from

  • Cattaneo, P.; Kunderfranco, P.; Greco, C.; Guffanti, A.; Stirparo, G.G.; Rusconi, F.; Rizzi, R.; Di Pasquale, E.; Locatelli, S.L.; Latronico, M.V.; Bearzi, C.; Papait, R.; Condorelli, G.
    DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation (2016), Cell Death Differ., 23, 555-564 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [histone H3]-L-lysine79 Mus musculus
-
 S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine79 Mus musculus
-
 S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Mus musculus
-
embryonic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [histone H3]-L-lysine79
-
 Mus musculus S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine79
-
 Mus musculus S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Synonyms

Synonyms Comment Organism
DOT1L disruptor of telomeric silencing 1-like Mus musculus

General Information

General Information Comment Organism
physiological function enzyme-mediated [histone H3]-N6,N6-dimethyl-L-lysine79 modification critically regulates gene expression during cardiomyocyte differentiation. DOTL1 is a key enzyme for cardiomyocyte differentiation and maturation Mus musculus