Literature summary for 2.1.1.360 extracted from

Wong, M.; Tee, A.E.L.; Milazzo, G.; Bell, J.L.; Poulos, R.C.; Atmadibrata, B.; Sun, Y.; Jing, D.; Ho, N.; Ling, D.; Liu, P.Y.; Zhang, X.D.; Huettelmaier, S.; Wong, J.W.H.; Wang, J.; Polly, P.; Perini, G.; Scarlett, C.J.; Liu, T.
The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription (2017), Cancer Res., 77, 2522-2533 .

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Application

Application	Comment	Organism
medicine	high levels of enzyme gene expression in human neuroblastoma tissues independently predict poor patient prognosis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
SGC0946	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79	Homo sapiens	overall reaction	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79	-	?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79	Homo sapiens	-	S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79	-	?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79	Homo sapiens	-	S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79	-	?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79	Homo sapiens	-	S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8TEK3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BE(2)-C cell	-	Homo sapiens	-
HEK-293 cell	-	Homo sapiens	-
NBL-5 cell	-	Homo sapiens	-
neuroblastoma cell	-	Homo sapiens	-
SK-N-FI cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79	overall reaction	Homo sapiens	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79	-	?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79	-	Homo sapiens	S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79	-	?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79	-	Homo sapiens	S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79	-	?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79	-	Homo sapiens	S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79	-	?

Subunits

Subunits	Comment	Organism
?	x * 185000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
DOT1L	-	Homo sapiens
KMT4	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown reduces histone H3 lysine 79 methylation and N-Myc protein binding at the ODC1 and E2F2 gene promoters and reduces neuroblastoma cell proliferation	Homo sapiens
physiological function	the enzyme is required for MYCN-amplified neuroblastoma cell proliferation	Homo sapiens

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Release 2023.1 (January 2023)