Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | histone H2B lysine ubiquitination is required for enzyme activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 | Homo sapiens | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TEK3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 | overall reaction | Homo sapiens | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DOT1L | - |
Homo sapiens |
H3K79 methylase | - |
Homo sapiens |
KMT4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme-mediated histone H3 lysine 79 methylation likely functions in transcription via the recruitment of reader proteins which act directly or indirectly to affect RNA polymerase II activity. Aberrant transcriptional activation via histone H3 lysine 79 methylation by the enzyme is implicated in the development of leukemias | Homo sapiens |