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Literature summary for 2.1.1.360 extracted from

  • Wood, K.; Tellier, M.; Murphy, S.
    DOT1L and H3K79 methylation in transcription and genomic stability (2018), Biomolecules, 8, E11 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information histone H2B lysine ubiquitination is required for enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens
-
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 Homo sapiens
-
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 Homo sapiens
-
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TEK3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79
-
Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79
-
Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
?

Synonyms

Synonyms Comment Organism
DOT1L
-
Homo sapiens
H3K79 methylase
-
Homo sapiens
KMT4
-
Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme-mediated histone H3 lysine 79 methylation likely functions in transcription via the recruitment of reader proteins which act directly or indirectly to affect RNA polymerase II activity. Aberrant transcriptional activation via histone H3 lysine 79 methylation by the enzyme is implicated in the development of leukemias Homo sapiens