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Literature summary for 2.1.1.360 extracted from
- Overexpression of grappa encoding a histone methyltransferase enhances stress resistance in Drosophila (2009), Hereditas, 146, 19-28.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histone L-lysine | Drosophila melanogaster | - |
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
vector insertion lines, GS13895 and GS17621 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histone L-lysine | - |
Drosophila melanogaster | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| histone lysine methyltransferase | - |
Drosophila melanogaster |
| HMT | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the gene grappa encoding a histone methyltransferase is required for normal lifespan and stress resistance, its overexpression increases stress resistance in Drosophila, without obvious induction of representative anti-oxidant genes | Drosophila melanogaster |
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