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Literature summary for 2.1.1.359 extracted from

  • Gautam, D.; Johnson, B.A.; Mac, M.; Moody, C.A.
    SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle (2018), PLoS Pathog., 14, e1007367 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Human papillomavirus type 16 overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 human papillomavirus 31 overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
human papillomavirus 31
-
-
-
Human papillomavirus type 16
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Human papillomavirus type 16 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction human papillomavirus 31 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
SETD2
-
 Human papillomavirus type 16
SETD2
-
 human papillomavirus 31

Expression

Organism Comment Expression
Human papillomavirus type 16 enzyme levels are increased in human papillomavirus-positive foreskin keratinocytes up
human papillomavirus 31 enzyme levels are increased in human papillomavirus-positive foreskin keratinocytes up

General Information

General Information Comment Organism
malfunction enzyme knockdown affects processing of late viral RNAs Human papillomavirus type 16
malfunction enzyme knockdown affects processing of late viral RNAs human papillomavirus 31
physiological function the enzyme regulates the viral life cycle through the recruitment of [histone H3]-N6,N6,N6-trimethyl-L-lysine36 readers to viral DNA and contributes to a productive viral replication Human papillomavirus type 16
physiological function the enzyme regulates the viral life cycle through the recruitment of [histone H3]-N6,N6,N6-trimethyl-L-lysine36 readers to viral DNA and contributes to a productive viral replication human papillomavirus 31