Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | Homo sapiens | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYW2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | overall reaction | Homo sapiens | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SETD2 | gene name, SET-domain containing 2 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown leads to defective repair of DNA double-strand breaks via the homologous recombination pathway | Homo sapiens |
physiological function | the enzyme plays an important role in stimulating [histone H3]-N6,N6,N6-trimethyl-L-lysine36 at a specifically generated DNA double-strand breaks site | Homo sapiens |