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Literature summary for 2.1.1.359 extracted from

  • Fuchs, S.M.; Kizer, K.O.; Braberg, H.; Krogan, N.J.; Strahl, B.D.
    RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36 (2012), J. Biol. Chem., 287, 3249-3256 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

General Stability

General Stability Organism
yeast mutants defective in RNA polymerase C-terminal domain phosphorylation at serine 2 show a destabilization of enzyme protein levels and histone H3 lysine 36 methylation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Saccharomyces cerevisiae overall reaction. Trimethylation of [histone H3]-L-lysine36 by the enzyme is directed through its association with the phosphorylated repeats of the RNA polymerase C-terminal domain 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
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 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Saccharomyces cerevisiae
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 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
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 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
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 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Saccharomyces cerevisiae
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 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P46995
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction. Trimethylation of [histone H3]-L-lysine36 by the enzyme is directed through its association with the phosphorylated repeats of the RNA polymerase C-terminal domain Saccharomyces cerevisiae 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
SET2
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 Saccharomyces cerevisiae