Activating Compound | Comment | Organism | Structure |
---|---|---|---|
histone H4 | in the presence of histone H4, there is a 5-7fold increase in enzyme activity on histone H3 | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | Saccharomyces cerevisiae | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | Saccharomyces cerevisiae BY4741 | overall reaction | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | Saccharomyces cerevisiae | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | Saccharomyces cerevisiae BY4741 | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | Saccharomyces cerevisiae | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | Saccharomyces cerevisiae BY4741 | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 | Saccharomyces cerevisiae | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 | Saccharomyces cerevisiae BY4741 | - |
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P46995 | - |
- |
Saccharomyces cerevisiae BY4741 | P46995 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | overall reaction | Saccharomyces cerevisiae | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | overall reaction | Saccharomyces cerevisiae BY4741 | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
additional information | the enzyme associates with the phosphorylated C-terminal domain of RNA polymerase II | Saccharomyces cerevisiae | ? | - |
? | |
additional information | the enzyme associates with the phosphorylated C-terminal domain of RNA polymerase II | Saccharomyces cerevisiae BY4741 | ? | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 | - |
Saccharomyces cerevisiae BY4741 | S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
Saccharomyces cerevisiae BY4741 | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
? | |
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 | - |
Saccharomyces cerevisiae BY4741 | S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SET2 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | the interaction between Set2 and histone H4 mediates trans-histone regulation of histone H3 lysine 36 methylation, which is needed for the preventative maintenance and integrity of the genome | Saccharomyces cerevisiae |