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Literature summary for 2.1.1.359 extracted from

  • Du, H.N.; Fingerman, I.M.; Briggs, S.D.
    Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4 (2008), Genes Dev., 22, 2786-2798 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Activating Compound

Activating Compound Comment Organism Structure
histone H4 in the presence of histone H4, there is a 5-7fold increase in enzyme activity on histone H3 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Saccharomyces cerevisiae overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Saccharomyces cerevisiae BY4741 overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Saccharomyces cerevisiae BY4741
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 Saccharomyces cerevisiae BY4741
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Saccharomyces cerevisiae BY4741
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P46995
-
-
Saccharomyces cerevisiae BY4741 P46995
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Saccharomyces cerevisiae 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Saccharomyces cerevisiae BY4741 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
additional information the enzyme associates with the phosphorylated C-terminal domain of RNA polymerase II Saccharomyces cerevisiae ?
-
 ?
additional information the enzyme associates with the phosphorylated C-terminal domain of RNA polymerase II Saccharomyces cerevisiae BY4741 ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Saccharomyces cerevisiae BY4741 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 Saccharomyces cerevisiae BY4741 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Saccharomyces cerevisiae BY4741 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
SET2
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the interaction between Set2 and histone H4 mediates trans-histone regulation of histone H3 lysine 36 methylation, which is needed for the preventative maintenance and integrity of the genome Saccharomyces cerevisiae