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Literature summary for 2.1.1.359 extracted from

  • Pfister, S.X.; Ahrabi, S.; Zalmas, L.P.; Sarkar, S.; Aymard, F.; Bachrati, C.Z.; Helleday, T.; Legube, G.; La Thangue, N.B.; Porter, A.C.; Humphrey, T.C.
    SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability (2014), Cell Rep., 7, 2006-2018 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYW2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
SETD2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown significantly reduces survival after treatment with mitomycin C, camptothecin, or ionizing radiation in U2OS cells and HeLa cells Homo sapiens
physiological function enzyme-dependent histone H3 lysine 36 trimethylation is required for homologous recombination repair and genome stability. The enzyme plays a presynaptic role for in homologous recombination, where it facilitates the recruitment of C-terminal binding protein interacting protein and promotes DNA double-strand break resection, allowing replication protein A and RAD51 binding to DNA damage sites Homo sapiens