Literature summary for 2.1.1.357 extracted from

Fang, D.; Gan, H.; Lee, J.; Han, J.; Wang, Z.; Riester, S.; Jin, L.; Chen, J.; Zhou, H.; Wang, J.; Zhang, H.; Yang, N.; Bradley, E.; Ho, T.; Rubin, B.; Bridge, J.; Thibodeau, S.; Ordog, T.; Chen, Y.; Van Wijnen, A.; Oliveira, A.; Xu, R.; Westendorf, J.
The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas (2016), Science, 352, 1344-1348 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
histone H3.3 K36M mutant protein	inhibits the H3K36 methyltransferases MMSET and SETD2	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36	Homo sapiens	overall reaction	2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36	-	?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36	Homo sapiens	-	S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36	-	?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36	Homo sapiens	-	S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondroblastoma cell	-	Homo sapiens	-
chondrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36	overall reaction	Homo sapiens	2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36	-	?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36	-	Homo sapiens	S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36	-	?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36	-	Homo sapiens	S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36	-	?

Synonyms

Synonyms	Comment	Organism
Ash1L	-	Homo sapiens
H3K36 methyltransferase	-	Homo sapiens
MMSET	-	Homo sapiens
NSD1	-	Homo sapiens
SETD2	-	Homo sapiens
Whsc1	-	Homo sapiens

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Release 2023.1 (January 2023)