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Literature summary for 2.1.1.357 extracted from

  • Wagner, E.; Carpenter, P.
    Understanding the language of Lys36 methylation at histone H3 (2012), Nat. Rev. Mol. Cell Biol., 13, 115-126 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.357

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens overall reaction 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-homocysteine + p65 subunit of nuclear factor-kappaB Homo sapiens
-
 ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Homo sapiens 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-homocysteine + p65 subunit of nuclear factor-kappaB
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
Ash1L
-
 Homo sapiens
H3K36 methyltransferase
-
 Homo sapiens
KMT3B
-
 Homo sapiens
MMSET
-
 Homo sapiens
NSD1
-
 Homo sapiens
NSD2
-
 Homo sapiens
SETMAR
-
 Homo sapiens
Smyd2
-
 Homo sapiens
Whsc1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction NSD1 enzyme mutants are associated with Sotos syndrome, myelodysplastic syndrome and cancer. NSD2 enzyme mutants are associated with Wolf-Hirschhorn syndrome and multiple myeloma Homo sapiens
physiological function the enzyme behaves as an oncogene in multiple cancers Homo sapiens