Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.357 extracted from

  • Qiao, Q.; Li, Y.; Chen, Z.; Wang, M.; Reinberg, D.; Xu, R.
    The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation (2011), J. Biol. Chem., 286, 8361-8368 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.357

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)-RIPL cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
catalytic domain, in 0.2 M lithium sulfate, 0.1 M HEPES, pH 7.5, and 25% (w/v) PEG 3350 at 20°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens overall reaction 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96L73
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose column chromatography and Superdex 75 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Homo sapiens 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
additional information the catalytic domain does not methylate recombinant nucleosomes containing histone H3 K36A mutants Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
NSD1
-
 Homo sapiens