Literature summary for 2.1.1.357 extracted from

Poulin, M.; Schneck, J.; Matico, R.; Hou, W.; McDevitt, P.; Holbert, M.; Schramm, V.
Nucleosome binding alters the substrate bonding environment of histone H3 lysine 36 methyltransferase NSD2 (2016), J. Am. Chem. Soc., 138, 6699-6702 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
histone H3K36M-containing polynucleosome	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 S-adenosyl-L-methionine + [histone H3]-L-lysine36	Homo sapiens	-	2 S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96028	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 S-adenosyl-L-methionine + [histone H3]-L-lysine36	-	Homo sapiens	2 S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36	-	?

Synonyms

Synonyms	Comment	Organism
H3K36-specific methyltransferase	-	Homo sapiens
histone H3 lysine 36 methyltransferase	-	Homo sapiens
NSD2	-	Homo sapiens
nuclear receptor-binding SET domain protein 2	-	Homo sapiens

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Release 2023.1 (January 2023)