Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.356 extracted from

  • Boros, J.; Arnoult, N.; Stroobant, V.; Collet, J.F.; Decottignies, A.
    Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1alpha at chromatin (2014), Mol. Cell. Biol., 34, 3662-3674 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.356

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine27 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61188
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine27
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 ?

Synonyms

Synonyms Comment Organism
EZH2 catalytic subunit Mus musculus
Polycomb repressive complex 2
-
 Mus musculus
PRC2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme depletion leads to heterochromatin protein 1alpha loss from chromatin and degradation Mus musculus
physiological function the enzyme and H3K27me3 cooperate with [histone H3]-L-lysine27 methylation to maintain heterochromatin protein 1alpha at chromatin Mus musculus