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Literature summary for 2.1.1.356 extracted from

  • Kim, J.Y.; Kee, H.J.; Choe, N.W.; Kim, S.M.; Eom, G.H.; Baek, H.J.; Kook, H.; Kook, H.; Seo, S.B.
    Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity (2008), Mol. Cell. Biol., 28, 2023-2034.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.356

Protein Variants

Protein Variants Comment Organism
C483A no activity, the SET domain cysteine 483 is a critical residue for the histone methyltransferase activity of RE-IIBP Homo sapiens
R477A no activity, the SET domain 477 is a critical residue for the histone methyltransferase activity of RE-IIBP Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H3(K27) RE-IIBP selectively transfers methyl groups to K27 of histone H3 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
histone lysine methyltransferase
-
 Homo sapiens
HMTase
-
 Homo sapiens
interleukin-5 response element II binding protein
-
 Homo sapiens
RE-IIBP
-
 Homo sapiens
WHSC1/MMSET isoform RE-IIBP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens RE-IIBP expression and histone methylation are increased in leukemia patients up

General Information

General Information Comment Organism
physiological function RE-IIBP represses basal transcription via histone deacetylase recruitment, which may be mediated by histone H3(K27) methylation, knockdown of RE-IIBP reduces histone H3-K27 methylation and histone deacetylase occupancy around the interleukin-5 promoter Homo sapiens